L M Westphal1, M L Polan, A Sontag Trant. 1. Department of Gynecology/Obstetrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Abstract
PURPOSE: To determine the impact of nutritional supplementation on female fertility. METHODS: A double blind, placebo-controlled study of the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry, green tea, L-arginine, vitamins (including folate) and minerals, on progesterone level, basal body temperature, menstrual cycle length, pregnancy rate and side-effects. RESULTS:Ninety-three (93) women, aged 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) group (N = 53) demonstrated a trend toward increased mean mid-luteal progesterone (P(ml)), but among women with basal pretreatment P(ml) < 9 ng/ml, the increase in progesterone was highly significant. The average number of days with luteal-phase basal temperatures over 98 degrees F increased significantly in the FB group. Both short and long cycles (< 27 days or > 32 days pretreatment) were normalized in the FB group. The placebo group (N = 40) did not show any significant changes in these parameters. After three months, 14 of the 53 women in the FB group were pregnant (26%) compared to four of the 40 women in the placebo group (10%; p = 0.01). Three additional women conceived after six months on FB (32%). No significant side-effects were noted. CONCLUSION: Nutritional supplements could provide an alternative or adjunct to conventional fertility therapies.
RCT Entities:
PURPOSE: To determine the impact of nutritional supplementation on female fertility. METHODS: A double blind, placebo-controlled study of the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry, green tea, L-arginine, vitamins (including folate) and minerals, on progesterone level, basal body temperature, menstrual cycle length, pregnancy rate and side-effects. RESULTS: Ninety-three (93) women, aged 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) group (N = 53) demonstrated a trend toward increased mean mid-luteal progesterone (P(ml)), but among women with basal pretreatment P(ml) < 9 ng/ml, the increase in progesterone was highly significant. The average number of days with luteal-phase basal temperatures over 98 degrees F increased significantly in the FB group. Both short and long cycles (< 27 days or > 32 days pretreatment) were normalized in the FB group. The placebo group (N = 40) did not show any significant changes in these parameters. After three months, 14 of the 53 women in the FB group were pregnant (26%) compared to four of the 40 women in the placebo group (10%; p = 0.01). Three additional women conceived after six months on FB (32%). No significant side-effects were noted. CONCLUSION: Nutritional supplements could provide an alternative or adjunct to conventional fertility therapies.
Authors: Heidi T Cueto; Anders H Riis; Elizabeth E Hatch; Lauren A Wise; Kenneth J Rothman; Henrik T Sørensen; Ellen M Mikkelsen Journal: Ann Epidemiol Date: 2015-06-04 Impact factor: 3.797
Authors: H T Cueto; A H Riis; E E Hatch; L A Wise; K J Rothman; H T Sørensen; E M Mikkelsen Journal: Eur J Clin Nutr Date: 2015-06-17 Impact factor: 4.016
Authors: Heidi T Cueto; Bjarke H Jacobsen; Anne Sofie Dam Laursen; Anders H Riis; Elizabeth E Hatch; Lauren A Wise; Ellen Trolle; Henrik Toft Sørensen; Kenneth J Rothman; Amelia K Wesselink; Sydney Willis; Benjamin R Johannesen; Ellen M Mikkelsen Journal: Hum Reprod Date: 2022-04-01 Impact factor: 6.918