OBJECTIVE: Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics. METHODS: Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were classified as aggressive or nonaggressive based on a comparison between the top third and bottom third scores on the Buss-Durkee Hostility Index. RESULTS: Using a pixel-wise comparison, no brain region showed significant alterations in SERT binding among the 3 groups of subjects (aggressive alcoholic subjects, nonaggressive alcoholic subjects, and healthy controls) or between the combined alcoholic group and healthy controls. None of the clinical measures (including measures of aggression) correlated with SERT binding in the alcoholic subjects. CONCLUSION: Contrary to prior imaging reports using the nonselective ligand [(123)I]beta-CIT, we found no significant alterations of SERT density in alcoholic patients.
OBJECTIVE:Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics. METHODS: Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were classified as aggressive or nonaggressive based on a comparison between the top third and bottom third scores on the Buss-Durkee Hostility Index. RESULTS: Using a pixel-wise comparison, no brain region showed significant alterations in SERT binding among the 3 groups of subjects (aggressive alcoholic subjects, nonaggressive alcoholic subjects, and healthy controls) or between the combined alcoholic group and healthy controls. None of the clinical measures (including measures of aggression) correlated with SERT binding in the alcoholic subjects. CONCLUSION: Contrary to prior imaging reports using the nonselective ligand [(123)I]beta-CIT, we found no significant alterations of SERT density in alcoholic patients.
Authors: Jian Hu; Shannan Henry; Jean-Dominique Gallezot; Jim Ropchan; John F Neumaier; Marc N Potenza; Rajita Sinha; John H Krystal; Yiyun Huang; Yu-Shin Ding; Richard E Carson; Alexander Neumeister Journal: Biol Psychiatry Date: 2010-02-20 Impact factor: 13.382
Authors: Martin Nørgaard; Melanie Ganz; Claus Svarer; Vibe G Frokjaer; Douglas N Greve; Stephen C Strother; Gitte M Knudsen Journal: Neuroimage Date: 2019-06-01 Impact factor: 6.556
Authors: Julie L Wang; Ajit K Parhi; Shunichi Oya; Brian Lieberman; Mei-Ping Kung; Hank F Kung Journal: Nucl Med Biol Date: 2008-05 Impact factor: 2.408
Authors: Dima A Hammoud; Christopher J Endres; Edward Hammond; Ovsev Uzuner; Amanda Brown; Avindra Nath; Adam I Kaplin; Martin G Pomper Journal: Neuroimage Date: 2009-10-21 Impact factor: 6.556
Authors: Brittany A Matthews; Stephen J Kish; Xin Xu; Isabelle Boileau; Pablo M Rusjan; Alan A Wilson; Dan DiGiacomo; Sylvain Houle; Jeffrey H Meyer Journal: Biol Psychiatry Date: 2013-10-12 Impact factor: 13.382