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Literature DB >> 21199778

Role of the serotonergic system in alcohol dependence: from animal models to clinics.

Youssef Sari¹, Verity R Johnson, Jason M Weedman.

Abstract

Alcohol dependence remains among the most common substance abuse problems worldwide, and compulsive alcohol consumption is a significant public health concern. Alcohol is an addictive drug that alters brain function through interactions with multiple neurotransmitter systems. These neurotransmitter systems mediate the reinforcing effects of alcohol. Specifically, the serotonergic system is important in mediating alcohol reward, preference, dependence, and craving. In this review chapter, we first discuss the serotonin system as it relates to alcoholism, and then outline interactions between this system and other neurotransmitter systems. We emphasize the serotonin transporter and its possible role in alcoholism, then present several serotonergic receptors and discuss their contribution to alcoholism, and finally assess the serotonin system as a target for pharmacotherapy, with an emphasis on current and potential treatments.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21199778 PMCID： PMC3508458 DOI： 10.1016/B978-0-12-385506-0.00010-7

Source DB: PubMed Journal: Prog Mol Biol Transl Sci ISSN： 1877-1173 Impact factor: 3.622

308 in total

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26 in total

Review 1. Neurochemical and neurostructural plasticity in alcoholism.

Authors: Justin T Gass; M Foster Olive
Journal: ACS Chem Neurosci Date: 2012-04-16 Impact factor: 4.418

Review 2. Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence.

Authors: Fawaz Alasmari; Sunil Goodwani; Robert E McCullumsmith; Youssef Sari
Journal: Prog Neurobiol Date: 2018-10-11 Impact factor: 11.685

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Journal: Alcohol Clin Exp Res Date: 2014-01-31 Impact factor: 3.455

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