BACKGROUND: Cystatin C, a marker of renal function, has been shown to be an independent predictor of cardiovascular disease (CVD) in older adults, but few data are available in middle-aged adults. Moreover, no study has compared cystatin C and microalbuminuria as risk factors for CVD outcomes in middle-aged adults, and it is not known whether cystatin C is related to an early stage of atherosclerosis. METHODS: We evaluated the relationships between serum creatinine, estimated glomerular filtration rate (GFR), serum cystatin C (all divided into tertiles), microalbuminuria and carotid atherosclerosis in a population-based random sample of 523 adults aged 35-64 years from the Seychelles (Indian Ocean). GFR was estimated using the modification of diet in renal disease (MDRD) equation. Intima-media thickness (IMT) was assessed by B-mode ultrasound. RESULTS: The mean age of the study sample was 52 years, and 55% were women. Carotid IMT was higher in participants with microalbuminuria (802 vs 732 microm, P<0.001) and was inversely associated with GFR tertiles (from 728 to 809 microm, P for trend=0.002). IMT was not associated with cystatin C or creatinine (P for trend=0.10 and 0.16, respectively). In multivariate analyses adjusted for cardiovascular risk factors, the association between microalbuminuria and IMT remained (P=0.047), while the association between GFR and IMT disappeared (P for trend=0.33). CONCLUSIONS: Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis beyond traditional cardiovascular risk factors among middle-aged adults. Cystatin C does not have a stronger relationship with carotid atherosclerosis in middle-aged adults than creatinine.
BACKGROUND:Cystatin C, a marker of renal function, has been shown to be an independent predictor of cardiovascular disease (CVD) in older adults, but few data are available in middle-aged adults. Moreover, no study has compared cystatin C and microalbuminuria as risk factors for CVD outcomes in middle-aged adults, and it is not known whether cystatin C is related to an early stage of atherosclerosis. METHODS: We evaluated the relationships between serum creatinine, estimated glomerular filtration rate (GFR), serum cystatin C (all divided into tertiles), microalbuminuria and carotid atherosclerosis in a population-based random sample of 523 adults aged 35-64 years from the Seychelles (Indian Ocean). GFR was estimated using the modification of diet in renal disease (MDRD) equation. Intima-media thickness (IMT) was assessed by B-mode ultrasound. RESULTS: The mean age of the study sample was 52 years, and 55% were women. Carotid IMT was higher in participants with microalbuminuria (802 vs 732 microm, P<0.001) and was inversely associated with GFR tertiles (from 728 to 809 microm, P for trend=0.002). IMT was not associated with cystatin C or creatinine (P for trend=0.10 and 0.16, respectively). In multivariate analyses adjusted for cardiovascular risk factors, the association between microalbuminuria and IMT remained (P=0.047), while the association between GFR and IMT disappeared (P for trend=0.33). CONCLUSIONS: Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis beyond traditional cardiovascular risk factors among middle-aged adults. Cystatin C does not have a stronger relationship with carotid atherosclerosis in middle-aged adults than creatinine.
Authors: Patrick Yerly; Nicolas Rodondi; Barathi Viswanathan; Walter Riesen; Pierre Vogt; Pascal Bovet Journal: Int J Cardiovasc Imaging Date: 2012-09-27 Impact factor: 2.357
Authors: M Gil-Ortega; C F García-Prieto; G Ruiz-Hurtado; C Steireif; M C González; A Schulz; R Kreutz; M S Fernández-Alfonso; S Arribas; B Somoza Journal: Br J Pharmacol Date: 2015-07-21 Impact factor: 8.739
Authors: Anh L Bui; Ronit Katz; Bryan Kestenbaum; Ian H de Boer; Linda F Fried; Joseph F Polak; Bruce A Wasserman; Mark J Sarnak; David Siscovick; Michael G Shlipak Journal: Am J Kidney Dis Date: 2008-09-27 Impact factor: 8.860
Authors: Andrew Moran; Ronit Katz; Nancy Swords Jenny; Brad Astor; David A Bluemke; João A C Lima; David Siscovick; Alain G Bertoni; Michael G Shlipak Journal: Am J Kidney Dis Date: 2008-10-08 Impact factor: 8.860
Authors: Crystal C Tyson; Patrick J Smith; Andrew Sherwood; Stephanie Mabe; Alan L Hinderliter; James A Blumenthal Journal: Clin Kidney J Date: 2017-05-02