Literature DB >> 1720570

Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.

A D Goddard1, J Borrow, P S Freemont, E Solomon.   

Abstract

The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (RARA) gene to the PML gene. Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products. PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically express only one fusion product, both PML/RARA (on the 15q+ derivative chromosome) and RARA/PML (on the 17q- derivative) are transcribed.

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Year:  1991        PMID： 1720570     DOI： 10.1126/science.1720570

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  114 in total

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