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Literature DB >> 17203952

Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.

Michael G Gravett¹, Archana Thomas, Kimberly A Schneider, Ashok P Reddy, Surendra Dasari, Thomas Jacob, Xinfang Lu, Matthew Rodland, Leonardo Pereira, Drew W Sadowsky, Charles T Roberts, Miles J Novy, Srinivasa R Nagalla.

Abstract

Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimensional protein identification technology (LC/LC-MS/MS) and MALDI-TOF-MS analyses. Analyses of CVF proteome identified 205 unique proteins and differential expression of 27 proteins in controls and IAI samples. Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI.

Entities: Disease

Mesh：

Substances：
Biomarkers

Year: 2007 PMID： 17203952 PMCID： PMC2532920 DOI： 10.1021/pr060149v

Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466

42 in total

1. The amniotic fluid cell proteome.

Authors: George Tsangaris; Rachel Weitzdörfer; Daniela Pollak; Gert Lubec; Michael Fountoulakis
Journal: Electrophoresis Date: 2005-03 Impact factor: 3.535

2. Open source system for analyzing, validating, and storing protein identification data.

Authors: Robertson Craig; John P Cortens; Ronald C Beavis
Journal: J Proteome Res Date: 2004 Nov-Dec Impact factor: 4.466

3. Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm.

Authors: Brian C Searle; Surendra Dasari; Phillip A Wilmarth; Mark Turner; Ashok P Reddy; Larry L David; Srinivasa R Nagalla
Journal: J Proteome Res Date: 2005 Mar-Apr Impact factor: 4.466

Review 4. Role of matrix metalloproteinases in preterm labour.

Authors: Felipe Vadillo-Ortega; Guadalupe Estrada-Gutiérrez
Journal: BJOG Date: 2005-03 Impact factor: 6.531

5. RL-37, an alpha-helical antimicrobial peptide of the rhesus monkey.

Authors: C Zhao; T Nguyen; L M Boo; T Hong; C Espiritu; D Orlov; W Wang; A Waring; R I Lehrer
Journal: Antimicrob Agents Chemother Date: 2001-10 Impact factor: 5.191

6. Births: final data for 2003.

Authors: Joyce A Martin; Brady E Hamilton; Paul D Sutton; Stephanie J Ventura; Fay Menacker; Martha L Munson
Journal: Natl Vital Stat Rep Date: 2005-09-08

7. Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation.

Authors: Irina A Buhimschi; Rob Christner; Catalin S Buhimschi
Journal: BJOG Date: 2005-02 Impact factor: 6.531

8. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery.

Authors: Rose-Marie Holst; Inger Mattsby-Baltzer; Ulla-Britt Wennerholm; Henrik Hagberg; Bo Jacobsson
Journal: Acta Obstet Gynecol Scand Date: 2005-06 Impact factor: 3.636

9. Correlation of relative abundance ratios derived from peptide ion chromatograms and spectrum counting for quantitative proteomic analysis using stable isotope labeling.

Authors: Boris Zybailov; Michael K Coleman; Laurence Florens; Michael P Washburn
Journal: Anal Chem Date: 2005-10-01 Impact factor: 6.986

10. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle.

Authors: Karine G Le Roch; Jeffrey R Johnson; Laurence Florens; Yingyao Zhou; Andrey Santrosyan; Munira Grainger; S Frank Yan; Kim C Williamson; Anthony A Holder; Daniel J Carucci; John R Yates; Elizabeth A Winzeler
Journal: Genome Res Date: 2004-11 Impact factor: 9.043

33 in total

1. Proteomic identification of serum peptides predicting subsequent spontaneous preterm birth.

Authors: M Sean Esplin; Karen Merrell; Robert Goldenberg; Yinglei Lai; Jay D Iams; Brian Mercer; Catherine Y Spong; Menachem Miodovnik; Hygriv N Simhan; Peter van Dorsten; Mitchell Dombrowski
Journal: Am J Obstet Gynecol Date: 2010-11-11 Impact factor: 8.661

2. Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.

Authors: Roberto Romero; Shali Mazaki-Tovi; Edi Vaisbuch; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Ricardo Gomez; Jyh Kae Nien; Bo Hyun Yoon; Moshe Mazor; Jingqin Luo; David Banks; John Ryals; Chris Beecher
Journal: J Matern Fetal Neonatal Med Date: 2010-05-26

3. The diagnostic performance of the Mass Restricted (MR) score in the identification of microbial invasion of the amniotic cavity or intra-amniotic inflammation is not superior to amniotic fluid interleukin-6.

Authors: Roberto Romero; Nicholas Kadar; Jezid Miranda; Steven J Korzeniewski; Alyse G Schwartz; Piya Chaemsaithong; Wade Rogers; Eleazar Soto; Francesca Gotsch; Lami Yeo; Sonia S Hassan; Tinnakorn Chaiworapongsa
Journal: J Matern Fetal Neonatal Med Date: 2013-12-16

Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.

1. The amniotic fluid cell proteome.

2. Open source system for analyzing, validating, and storing protein identification data.

3. Identification of protein modifications using MS/MS de novo sequencing and the OpenSea alignment algorithm.

Review 4. Role of matrix metalloproteinases in preterm labour.

5. RL-37, an alpha-helical antimicrobial peptide of the rhesus monkey.

6. Births: final data for 2003.

7. Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation.

8. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery.

9. Correlation of relative abundance ratios derived from peptide ion chromatograms and spectrum counting for quantitative proteomic analysis using stable isotope labeling.

10. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle.

1. Proteomic identification of serum peptides predicting subsequent spontaneous preterm birth.

2. Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.

3. The diagnostic performance of the Mass Restricted (MR) score in the identification of microbial invasion of the amniotic cavity or intra-amniotic inflammation is not superior to amniotic fluid interleukin-6.

4. Contemporary diagnosis and management of preterm premature rupture of membranes.

5. Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid.

Review 6. Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth.

7. Proteomic analysis of menstrual blood.

Review 8. Advances in medical diagnosis of intra-amniotic infection.

9. Global report on preterm birth and stillbirth (2 of 7): discovery science.

10. Characterization of the Human Cervical Mucous Proteome.