BACKGROUND: FGFR-2 and FGFR-3 (fibroblast growth factor receptors) have been shown to play an important role in several processes including carcinogenesis. This study was designed to determine gradual FGFR-2 and FGFR-3 expression in sequential stages of oral carcinogenesis in an experimental animal system of Syrian golden hamsters. MATERIALS AND METHODS: Tissue sections ranging from normal mucosa to squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins. RESULTS: A significant elevation was revealed in both FGFR-2 and FGFR-3 expression during the stages of dysplasia and early invasion, while in the later stages of oral carcinogenesis the expression of both FGFR-2 and FGFR-3 decreased although not significantly. CONCLUSION: Our findings indicate that FGFR-2 and FGFR-3 seem to play an important role in the initial stages of oral cancer progression.
BACKGROUND:FGFR-2 and FGFR-3 (fibroblast growth factor receptors) have been shown to play an important role in several processes including carcinogenesis. This study was designed to determine gradual FGFR-2 and FGFR-3 expression in sequential stages of oral carcinogenesis in an experimental animal system of Syrian golden hamsters. MATERIALS AND METHODS: Tissue sections ranging from normal mucosa to squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins. RESULTS: A significant elevation was revealed in both FGFR-2 and FGFR-3 expression during the stages of dysplasia and early invasion, while in the later stages of oral carcinogenesis the expression of both FGFR-2 and FGFR-3 decreased although not significantly. CONCLUSION: Our findings indicate that FGFR-2 and FGFR-3 seem to play an important role in the initial stages of oral cancer progression.
Authors: Zhiyong Liu; Yolanda E Hartman; Jason M Warram; Joseph A Knowles; Larissa Sweeny; Tong Zhou; Eben L Rosenthal Journal: Mol Cancer Res Date: 2011-06-10 Impact factor: 5.852
Authors: Tomasz Kolenda; Weronika Przybyła; Marta Kapałczyńska; Anna Teresiak; Maria Zajączkowska; Renata Bliźniak; Katarzyna M Lamperska Journal: Rep Pract Oncol Radiother Date: 2018-03-17
Authors: Dhruv Kumar; Jacob New; Vikalp Vishwakarma; Radhika Joshi; Jonathan Enders; Fangchen Lin; Sumana Dasari; Wade R Gutierrez; George Leef; Sivapriya Ponnurangam; Hemantkumar Chavan; Lydia Ganaden; Mackenzie M Thornton; Hongying Dai; Ossama Tawfik; Jeffrey Straub; Yelizaveta Shnayder; Kiran Kakarala; Terance Ted Tsue; Douglas A Girod; Bennett Van Houten; Shrikant Anant; Partha Krishnamurthy; Sufi Mary Thomas Journal: Cancer Res Date: 2018-05-16 Impact factor: 12.701
Authors: Sandra Perdomo; Devasena Anantharaman; Matthieu Foll; Behnoush Abedi-Ardekani; Geoffroy Durand; Luciana Albina Reis Rosa; Reetta Holmila; Florence Le Calvez-Kelm; Eloiza H Tajara; Victor Wünsch-Filho; José Eduardo Levi; Marta Vilensky; Jerry Polesel; Ivana Holcatova; Lorenzo Simonato; Cristina Canova; Pagona Lagiou; James D McKay; Paul Brennan Journal: PLoS One Date: 2018-01-29 Impact factor: 3.240