Literature DB >> 29760589

Tumor microenvironment - Unknown niche with powerful therapeutic potential.

Tomasz Kolenda1,2,3, Weronika Przybyła1,4, Marta Kapałczyńska1,5,6, Anna Teresiak1, Maria Zajączkowska1,3, Renata Bliźniak1, Katarzyna M Lamperska1.   

Abstract

Head and neck squamous cell carcinomas (HNSCC) are in a group of cancers that are the most resistant to treatment. The survival rate of HNSCC patients has been still very low since last 20 years. The existence of relationship between oncogenic and surrounding cells is probably the reason for a poor response to treatment. Fibroblasts are an important element of tumor stroma which increases tumor cells ability to proliferate. Another highly resistance, tumorigenic and metastatic cell population in tumor microenvironment are cancer initiating cells (CICs). The population of cancer initiating cells can be found regardless of differentiation status of cancer and they seem to be crucial for HNSCC development. In this review, we describe the current state of knowledge about HNSCC biological and physiological tumor microenvironment.

Entities:  

Keywords:  Cancer stem cells; HNSCC; Metastasis; Resistance to therapy; Tumor initiating cells; Tumor microenvironment

Year:  2018        PMID： 29760589      PMCID： PMC5948324          DOI： 10.1016/j.rpor.2018.01.004

Source DB:  PubMed          Journal:  Rep Pract Oncol Radiother        ISSN： 1507-1367


  125 in total

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