| Literature DB >> 17199135 |
Q Wei1, M Li, X Fu, R Tang, Y Na, M Jiang, Y Li.
Abstract
Progression to androgen independent (AI) is the main cause of death in prostate cancer, and the mechanism is still unclear. By reviewing the expression profiles of 26 prostate cancer samples in a holistic view, we found a group of genes differentially expressed in AI compared with androgen-dependent groups (P-value<0.01, t-test). Focusing on apoptosis, proliferation, hormone and angiogenesis, we found a group of genes such as thioredoxin domain containing 5 , tumor necrosis factor receptor superfamily, member 10a , ribosomal protein S19 and Janus kinase 2 upregulated in AI prostate cancer, could play important roles in the transition from AD to AI and could be biomarkers of prognosis.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17199135 DOI： 10.1038/sj.pcan.4500933
Source DB: PubMed Journal: Prostate Cancer Prostatic Dis ISSN： 1365-7852 Impact factor: 5.554