Literature DB >> 17192109

Total synthesis of potential antitumor agent, (-)-dictyostatin.

P Veeraraghavan Ramachandran1, Amit Srivastava, Debasis Hazra.   

Abstract

[structure: see text] The potential antitumor agent (-)-dictyostatin has been synthesized utilizing Brown crotylboration to achieve eight of the eleven chiral centers. The yield for the 26-step longest sequence is approximately 4%. The C9-C10 coupling is achieved via a stereoselective vinylzincate addition.

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Year:  2007        PMID： 17192109     DOI： 10.1021/ol062737k

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

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4.  Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

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6.  A multifaceted phosphate tether: application to the C1-C14 subunit of dolabelides A-D.

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7.  Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts.

Authors:  Julie L Eiseman; Lihua Bai; Won-Hyuk Jung; Gustavo Moura-Letts; Billy W Day; Dennis P Curran
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8.  A highly step-economical synthesis of dictyostatin.

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9.  Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.

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Journal:  Tetrahedron       Date:  2007-08-27       Impact factor: 2.457

10.  Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents.

Authors:  María Jiménez; Wei Zhu; Andreas Vogt; Billy W Day; Dennis P Curran
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