PURPOSE: To investigate the effects of oral cannabinoids on retinal hemodynamics assessed by video fluorescein angiography in healthy subjects. DESIGN: Interventional study. METHODS: In a self-experiment, the cannabinoid dronabinol (delta-9-tetrahydrocannabinol [THC]) was administered orally to eight healthy medical doctors (7.5 mg Marinol; Unimed Pharmaceuticals, Chicago, Illinois, USA). At baseline and two hours after dronabinol intake, intraocular pressure (IOP) was measured and retinal hemodynamics were assessed by fluorescein angiography. The retinal arteriovenous passage time was determined on the basis of dye dilution curves by means of digital image analysis in a masked fashion. RESULTS: Dronabinol resulted in a significant IOP reduction from 13.2 +/- 1.9 mm Hg to 11.8 +/- 2.0 mm Hg (P = .038). The retinal arteriovenous passage time decreased from 1.77 +/- 0.35 seconds to 1.57 +/- 0.31 seconds (P = .028). Systemic blood pressure and heart rate were not statistically significantly altered. CONCLUSIONS: Cannabinoids, already known for their ability to reduce IOP, may result in increased retinal hemodynamics. This may be beneficial in ocular circulatory disorders, including glaucoma.
PURPOSE: To investigate the effects of oral cannabinoids on retinal hemodynamics assessed by video fluorescein angiography in healthy subjects. DESIGN: Interventional study. METHODS: In a self-experiment, the cannabinoiddronabinol (delta-9-tetrahydrocannabinol [THC]) was administered orally to eight healthy medical doctors (7.5 mg Marinol; Unimed Pharmaceuticals, Chicago, Illinois, USA). At baseline and two hours after dronabinol intake, intraocular pressure (IOP) was measured and retinal hemodynamics were assessed by fluorescein angiography. The retinal arteriovenous passage time was determined on the basis of dye dilution curves by means of digital image analysis in a masked fashion. RESULTS:Dronabinol resulted in a significant IOP reduction from 13.2 +/- 1.9 mm Hg to 11.8 +/- 2.0 mm Hg (P = .038). The retinal arteriovenous passage time decreased from 1.77 +/- 0.35 seconds to 1.57 +/- 0.31 seconds (P = .028). Systemic blood pressure and heart rate were not statistically significantly altered. CONCLUSIONS:Cannabinoids, already known for their ability to reduce IOP, may result in increased retinal hemodynamics. This may be beneficial in ocular circulatory disorders, including glaucoma.
Authors: Mohamed M Radwan; Mahmoud A ElSohly; Abir T El-Alfy; Safwat A Ahmed; Desmond Slade; Afeef S Husni; Susan P Manly; Lisa Wilson; Suzanne Seale; Stephen J Cutler; Samir A Ross Journal: J Nat Prod Date: 2015-05-22 Impact factor: 4.050
Authors: Safwat A Ahmed; Samir A Ross; Desmond Slade; Mohamed M Radwan; Ikhlas A Khan; Mahmoud A Elsohly Journal: Tetrahedron Lett Date: 2008-10-13 Impact factor: 2.415
Authors: Safwat A Ahmed; Samir A Ross; Desmond Slade; Mohamed M Radwan; Fazila Zulfiqar; Rae R Matsumoto; Yan-Tong Xu; Eddy Viard; Robert C Speth; Vardan T Karamyan; M A ElSohly Journal: J Nat Prod Date: 2008-02-28 Impact factor: 4.050
Authors: Nikolaus Hommer; Martin Kallab; Stephan Szegedi; Stefan Puchner; Kristina Stjepanek; Martin Bauer; René M Werkmeister; Leopold Schmetterer; Marihan Abensperg-Traun; Gerhard Garhöfer; Doreen Schmidl Journal: Clin Pharmacol Ther Date: 2020-02-23 Impact factor: 6.875