Literature DB >> 17186373

Does Abeta 42 have a function related to blood homeostasis?

John Hardy1.   

Abstract

In this review, I discuss the possibility that Abeta42 has a physiologic function in blood vessel homeostasis and the consequences that this might have for theories concerning the pathogenesis of Alzheimer's disease and for treatment.

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Year:  2006        PMID： 17186373     DOI： 10.1007/s11064-006-9221-9

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  24 in total

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3.  APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.

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4.  Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.

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5.  Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein.

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Journal:  Science       Date:  1990-05-11       Impact factor: 47.728

Review 6.  An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease.

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Review 8.  Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage.

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Review 9.  Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply.

Authors:  Craig S Atwood; Richard L Bowen; Mark A Smith; George Perry
Journal:  Brain Res Brain Res Rev       Date:  2003-09

Review 10.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Authors:  John Hardy; Dennis J Selkoe
Journal:  Science       Date:  2002-07-19       Impact factor: 47.728
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  10 in total

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