Literature DB >> 17183361

Capturing cyclic nucleotides in action: snapshots from crystallographic studies.

Holger Rehmann1, Alfred Wittinghofer, Johannes L Bos.   

Abstract

Fifty years ago, cyclic AMP was discovered as a second messenger of hormone action, heralding the age of signal transduction. Many cellular processes were found to be regulated by cAMP and the related cyclic GMP. Cyclic nucleotides function by binding to and activating their effectors - protein kinase A, protein kinase G, cyclic-nucleotide-regulated ion channels and the guanine nucleotide-exchange factor Epac. Recent structural insights have now made it possible to propose a general structural mechanism for how cyclic nucleotides regulate these proteins.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17183361     DOI： 10.1038/nrm2082

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  97 in total

Review 1.  Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

Authors:  Euan Parnell; Brian O Smith; Timothy M Palmer; Anna Terrin; Manuela Zaccolo; Stephen J Yarwood
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

2.  Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.

Authors:  Nadine L Wicks; Tammy Wong; Jinyi Sun; Zarina Madden; Edgar C Young
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

3.  Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling.

Authors:  Jimena Rinaldi; Jian Wu; Jie Yang; Corie Y Ralston; Banumathi Sankaran; Silvia Moreno; Susan S Taylor
Journal:  Structure       Date:  2010-11-10       Impact factor: 5.006

4.  cAMP-regulated protein lysine acetylases in mycobacteria.

Authors:  Subhalaxmi Nambi; Nirmalya Basu; Sandhya S Visweswariah
Journal:  J Biol Chem       Date:  2010-05-27       Impact factor: 5.157

Review 5.  The enigmatic cytoplasmic regions of KCNH channels.

Authors:  João H Morais-Cabral; Gail A Robertson
Journal:  J Mol Biol       Date:  2014-08-23       Impact factor: 5.469

6.  Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Authors:  Rahul Das; Somenath Chowdhury; Mohammad T Mazhab-Jafari; Soumita Sildas; Rajeevan Selvaratnam; Giuseppe Melacini
Journal:  J Biol Chem       Date:  2009-04-29       Impact factor: 5.157

7.  N 6-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels.

Authors:  Tim Leypold; Michele Bonus; Felix Spiegelhalter; Frank Schwede; Tina Schwabe; Holger Gohlke; Jana Kusch
Journal:  J Biol Chem       Date:  2019-10-15       Impact factor: 5.157

Review 8.  NMR reveals novel mechanisms of protein activity regulation.

Authors:  Charalampos G Kalodimos
Journal:  Protein Sci       Date:  2011-04-08       Impact factor: 6.725

Review 9.  Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.

Authors:  George G Holz; Oleg G Chepurny; Frank Schwede
Journal:  Cell Signal       Date:  2007-07-25       Impact factor: 4.315

10.  A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channels.

Authors:  Michael C Puljung; William N Zagotta
Journal:  J Biol Chem       Date:  2013-03-22       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.