Literature DB >> 17181137

Structure-brain exposure relationships.

Stephen A Hitchcock1, Lewis D Pennington.   

Abstract

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Substances：

Year:  2006        PMID： 17181137     DOI： 10.1021/jm060642i

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  112 in total

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Journal:  ACS Chem Neurosci       Date:  2010-03-25       Impact factor: 4.418

2.  Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues.

Authors:  Jiachen Wen; Kelly A Teske; M Kyle Hadden
Journal:  Bioorg Med Chem Lett       Date:  2019-11-09       Impact factor: 2.823

3.  Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.

Authors:  Liuyin Zhang; Charles R Robertson; Brad R Green; Timothy H Pruess; H Steve White; Grzegorz Bulaj
Journal:  J Med Chem       Date:  2009-03-12       Impact factor: 7.446

4.  An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.

Authors:  Yuan Cheng; James Brown; Ted C Judd; Patricia Lopez; Wenyuan Qian; Timothy S Powers; Jian Jeffrey Chen; Michael D Bartberger; Kui Chen; Robert T Dunn; Oleg Epstein; Robert T Fremeau; Scott Harried; Dean Hickman; Stephen A Hitchcock; Yi Luo; Ana Elena Minatti; Vinod F Patel; Hugo M Vargas; Robert C Wahl; Matthew M Weiss; Paul H Wen; Ryan D White; Douglas A Whittington; Xiao Mei Zheng; Stephen Wood
Journal:  ACS Med Chem Lett       Date:  2014-12-29       Impact factor: 4.345

5.  Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.

Authors:  Hualong Fu; Weiting Tang; Zhen Chen; Vasily V Belov; Genwei Zhang; Tuo Shao; Xiaofei Zhang; Qingzhen Yu; Jian Rong; Xiaoyun Deng; Wei Han; Scott J Myers; Pilar Giffenig; Lu Wang; Lee Josephson; Yihan Shao; April T Davenport; James B Daunais; Mikhail Papisov; Hongjie Yuan; Zijing Li; Stephen F Traynelis; Steven H Liang
Journal:  ACS Chem Neurosci       Date:  2019-02-27       Impact factor: 4.418

6.  Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies.

Authors:  Chunyang Jin; Ann M Decker; Danni L Harris; Bruce E Blough
Journal:  ACS Chem Neurosci       Date:  2016-08-16       Impact factor: 4.418

7.  Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy.

Authors:  J Matthew Meinig; Skylar J Ferrara; Tania Banerji; Tapasree Banerji; Hannah S Sanford-Crane; Dennis Bourdette; Thomas S Scanlan
Journal:  ACS Chem Neurosci       Date:  2017-08-18       Impact factor: 4.418

8.  Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.

Authors:  ThanhTruc Pham; Madeline Walden; Christopher Butler; Rosario Diaz-Gonzalez; Guiomar Pérez-Moreno; Gloria Ceballos-Pérez; Veronica Gomez-Pérez; Raquel García-Hernández; Henry Zecca; Emma Krakoff; Brian Kopec; Ogar Ichire; Caden Mackenzie; Marika Pitot; Luis Miguel Ruiz; Francisco Gamarro; Dolores González-Pacanowska; Miguel Navarro; Amy B Dounay
Journal:  Bioorg Med Chem Lett       Date:  2017-07-11       Impact factor: 2.823

9.  Anticancer potential of aminomethylidene-diazinanes I. Synthesis of arylaminomethylidene of diazinetriones and its cytotoxic effects tested in glioblastoma cells.

Authors:  Nichole A Pianovich; Mathew Dean; Adam Lassak; Krzysztof Reiss; Branko S Jursic
Journal:  Bioorg Med Chem       Date:  2017-08-12       Impact factor: 3.641

10.  Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability.

Authors:  Brandon J Turunen; Haibo Ge; Jariat Oyetunji; Kelly E Desino; Veena Vasandani; Sarah Güthe; Richard H Himes; Kenneth L Audus; Anna Seelig; Gunda I Georg
Journal:  Bioorg Med Chem Lett       Date:  2008-10-02       Impact factor: 2.823
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