Literature DB >> 17180876

Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease.

Daniela Puzzo1, Agostino Palmeri, Ottavio Arancio.   

Abstract

Amyloid-beta (Abeta), a peptide thought to play a crucial role in Alzheimer's disease (AD), has attracted scientific interest with the aim of characterizing the mechanisms by which it is involved in AD pathogenesis. Abeta has been found to markedly impair hippocampal long-term potentiation (LTP), a widely studied cellular model of synaptic plasticity that is thought to underlie learning and memory. The overall purpose of this review is to define the role of the nitric oxide (NO)/cGMP/cAMP-regulatory element binding (CREB) pathway in beta-amyloid-induced changes of basal neurotransmission and synaptic plasticity in the hippocampus, a structure within the temporal lobe of the brain critical for memory storage.

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Year:  2006        PMID： 17180876     DOI： 10.1515/revneuro.2006.17.5.497

Source DB:  PubMed          Journal:  Rev Neurosci        ISSN： 0334-1763            Impact factor:   4.353


  22 in total

1.  Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents.

Authors:  Isaac T Schiefer; Lawren VandeVrede; Mauro Fa'; Ottavio Arancio; Gregory R J Thatcher
Journal:  J Med Chem       Date:  2012-03-30       Impact factor: 7.446

2.  Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Authors:  Zhihui Qin; Jia Luo; Lawren VandeVrede; Ehsan Tavassoli; Mauro Fa'; Andrew F Teich; Ottavio Arancio; Gregory R J Thatcher
Journal:  J Med Chem       Date:  2012-07-24       Impact factor: 7.446

3.  Furoxans (Oxadiazole-4 N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory.

Authors:  Austin Horton; Kevin Nash; Ethel Tackie-Yarboi; Alexander Kostrevski; Adam Novak; Aparna Raghavan; Jatin Tulsulkar; Qasim Alhadidi; Nathan Wamer; Bryn Langenderfer; Kalee Royster; Maxwell Ducharme; Katelyn Hagood; Megan Post; Zahoor A Shah; Isaac T Schiefer
Journal:  J Med Chem       Date:  2018-05-07       Impact factor: 7.446

4.  Regulation of IL-1β-induced cyclooxygenase-2 expression by interactions of Aβ peptide, apolipoprotein E and nitric oxide in human neuroglioma.

Authors:  Anju S Samy; Orisa J Igwe
Journal:  J Mol Neurosci       Date:  2011-11-19       Impact factor: 3.444

5.  Pharmacological modulators of nitric oxide signaling and contextual fear conditioning in mice.

Authors:  Jonathan B Kelley; Karen L Anderson; Yossef Itzhak
Journal:  Psychopharmacology (Berl)       Date:  2010-03-12       Impact factor: 4.530

Review 6.  Synaptic therapy in Alzheimer's disease: a CREB-centric approach.

Authors:  Andrew F Teich; Russell E Nicholls; Daniela Puzzo; Jole Fiorito; Rosa Purgatorio; Mauro Fa'; Ottavio Arancio
Journal:  Neurotherapeutics       Date:  2015-01       Impact factor: 7.620

7.  Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity.

Authors:  Scott E Counts; Elliott J Mufson
Journal:  J Neurochem       Date:  2010-02-01       Impact factor: 5.372

Review 8.  Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity.

Authors:  Roberto Cappai; Kevin J Barnham
Journal:  Neurochem Res       Date:  2007-08-31       Impact factor: 3.996

9.  Differential role of the nNOS gene in the development of behavioral sensitization to cocaine in adolescent and adult B6;129S mice.

Authors:  Mara A Balda; Karen L Anderson; Yossef Itzhak
Journal:  Psychopharmacology (Berl)       Date:  2008-07-01       Impact factor: 4.530

10.  Impairments in fear conditioning in mice lacking the nNOS gene.

Authors:  Jonathan B Kelley; Mara A Balda; Karen L Anderson; Yossef Itzhak
Journal:  Learn Mem       Date:  2009-05-23       Impact factor: 2.460
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