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Literature DB >> 17762917

Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity.

Abstract

The Alzheimer's disease neurotoxic amyloid-beta (A beta) peptide is derived from the larger amyloid precursor protein (APP) and is the principal component of the senile plaques in Alzheimer's disease (AD) brains. This mechanism by which A beta mediates neurotoxicity or neuronal dysfunction is not fully resolved. This review will outline some of the key determinants that modulate A beta's activity and the cellular pathways and mechanisms involved.

Entities: Disease Gene

Mesh：

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Year: 2007 PMID： 17762917 DOI： 10.1007/s11064-007-9469-8

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

103 in total

1. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.

Authors: C A McLean; R A Cherny; F W Fraser; S J Fuller; M J Smith; K Beyreuther; A I Bush; C L Masters
Journal: Ann Neurol Date: 1999-12 Impact factor: 10.422

2. Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology.

Authors: H Lin; R Bhatia; R Lal
Journal: FASEB J Date: 2001-11 Impact factor: 5.191

3. Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

Authors: Stefan Barghorn; Volker Nimmrich; Andreas Striebinger; Carsten Krantz; Patrick Keller; Bodo Janson; Michael Bahr; Martin Schmidt; Robert S Bitner; John Harlan; Eve Barlow; Ulrich Ebert; Heinz Hillen
Journal: J Neurochem Date: 2005-08-31 Impact factor: 5.372

4. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

Authors: J Lewis; D W Dickson; W L Lin; L Chisholm; A Corral; G Jones; S H Yen; N Sahara; L Skipper; D Yager; C Eckman; J Hardy; M Hutton; E McGowan
Journal: Science Date: 2001-08-24 Impact factor: 47.728

5. Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus.

Authors: Sung Hwan Yun; Georgi Gamkrelidze; W Blaine Stine; Patrick M Sullivan; Joseph F Pasternak; Mary Jo Ladu; Barbara L Trommer
Journal: Neurosci Lett Date: 2006-06-12 Impact factor: 3.046

Review 6. Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics.

Authors: D Allan Butterfield; Marzia Perluigi; Rukhsana Sultana
Journal: Eur J Pharmacol Date: 2006-06-15 Impact factor: 4.432

7. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

Authors: Yan Zhang; Yanguo Hong; Younes Bounhar; Megan Blacker; Xavier Roucou; Omar Tounekti; Emily Vereker; William J Bowers; Howard J Federoff; Cynthia G Goodyer; Andrea LeBlanc
Journal: J Neurosci Date: 2003-08-13 Impact factor: 6.167

8. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

Authors: Jeannie Chin; Jorge J Palop; Gui-Qiu Yu; Nobuhiko Kojima; Eliezer Masliah; Lennart Mucke
Journal: J Neurosci Date: 2004-05-12 Impact factor: 6.167

Review 9. Molecular mechanisms of cellular injury produced by neurotoxic amino acids that generate reactive oxygen species.

Authors: D Metodiewa
Journal: Amino Acids Date: 1998 Impact factor: 3.520

10. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

Authors: Carlos Opazo; Xudong Huang; Robert A Cherny; Robert D Moir; Alex E Roher; Anthony R White; Roberto Cappai; Colin L Masters; Rudolph E Tanzi; Nibaldo C Inestrosa; Ashley I Bush
Journal: J Biol Chem Date: 2002-08-20 Impact factor: 5.157

33 in total

1. Adsorption mechanism and collapse propensities of the full-length, monomeric Aβ(1-42) on the surface of a single-walled carbon nanotube: a molecular dynamics simulation study.

Authors: Asis K Jana; Neelanjana Sengupta
Journal: Biophys J Date: 2012-04-18 Impact factor: 4.033

2. Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease.

Authors: Victor L Villemagne; Keyla A Perez; Kerryn E Pike; W Mei Kok; Christopher C Rowe; Anthony R White; Pierrick Bourgeat; Olivier Salvado; Justin Bedo; Craig A Hutton; Noel G Faux; Colin L Masters; Kevin J Barnham
Journal: J Neurosci Date: 2010-05-05 Impact factor: 6.167

3. Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

Authors: Joseph J Braymer; Jung-Suk Choi; Alaina S DeToma; Chen Wang; Kisoo Nam; Jeffrey W Kampf; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal: Inorg Chem Date: 2011-09-28 Impact factor: 5.165

4. Molecular dynamics simulation studies of the structural response of an isolated Aβ1-42 monomer localized in the vicinity of the hydrophilic TiO 2 surface.

Authors: Jaya C Jose; Neelanjana Sengupta
Journal: Eur Biophys J Date: 2013-04-12 Impact factor: 1.733