Literature DB >> 1717893

Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs.

D C Bolser1, S M Aziz, R W Chapman.   

Abstract

The influence of aerosols of Ruthenium red (RR) on capsaicin- and citric acid-induced cough was investigated in guinea pigs. Aerosols of RR (0.3, 1, 3%) reduced capsaicin-induced cough in dose-dependent manner. Inhalation of RR also reduced cough produced by low, (200 mM) but not high (550 mM), concentrations of citric acid. These data suggest that RR is not a specific capsaicin antagonist and that citric acid and capsaicin share a common mechanism for activation of airway C-fibers that is RR sensitive. Furthermore, high concentrations of citric acid can elicit cough through a RR-insensitive mechanism.

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Year:  1991        PMID： 1717893     DOI： 10.1016/0304-3940(91)90536-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


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