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Literature DB >> 19074743

Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.

Abstract

New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome.

Entities: CellLine Chemical Disease Gene Species

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Year: 2008 PMID： 19074743 PMCID： PMC2735846 DOI： 10.1152/physiol.00026.2008

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

137 in total

1. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation.

Authors: José A Matta; Paul M Cornett; Rosa L Miyares; Ken Abe; Niaz Sahibzada; Gerard P Ahern
Journal: Proc Natl Acad Sci U S A Date: 2008-06-23 Impact factor: 11.205

2. The worker with multiple chemical sensitivities: an overview.

Authors: M R Cullen
Journal: Occup Med Date: 1987 Oct-Dec

3. Sensory irritation response to inhaled aldehydes after formaldehyde pretreatment.

Authors: C Babiuk; W H Steinhagen; C S Barrow
Journal: Toxicol Appl Pharmacol Date: 1985-06-15 Impact factor: 4.219

4. Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation.

Authors: Takeo Nakajima; Yoshihiro Nishimura; Teruaki Nishiuma; Yoshikazu Kotani; Hiroyuki Nakata; Mitsuhiro Yokoyama
Journal: Allergol Int Date: 2006-06 Impact factor: 5.836

5. Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig.

Authors: Marian Kollarik; Bradley J Undem
Journal: J Physiol Date: 2002-09-01 Impact factor: 5.182

6. A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man.

Authors: E A Laude; K S Higgins; A H Morice
Journal: Pulm Pharmacol Date: 1993-09

7. Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1.

Authors: Serena Materazzi; Romina Nassini; Eunice Andrè; Barbara Campi; Silvia Amadesi; Marcello Trevisani; Nigel W Bunnett; Riccardo Patacchini; Pierangelo Geppetti
Journal: Proc Natl Acad Sci U S A Date: 2008-08-07 Impact factor: 11.205

8. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity.

Authors: Elizabeth D Prescott; David Julius
Journal: Science Date: 2003-05-23 Impact factor: 47.728

9. Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.

Authors: Anindya Bhattacharya; Brian P Scott; Nadia Nasser; Hong Ao; Michael P Maher; Adrienne E Dubin; Devin M Swanson; Nigel P Shankley; Alan D Wickenden; Sandra R Chaplan
Journal: J Pharmacol Exp Ther Date: 2007-08-09 Impact factor: 4.030

10. Capsaicin evokes secretion of nasal fluid and depletes substance P and calcitonin gene-related peptide from the nasal mucosa in the rat.

Authors: G Petersson; L Malm; R Ekman; R Håkanson
Journal: Br J Pharmacol Date: 1989-11 Impact factor: 8.739

163 in total

Review 1. Chemesthesis and the chemical senses as components of a "chemofensor complex".

Authors: Barry G Green
Journal: Chem Senses Date: 2011-12-30 Impact factor: 3.160

2. Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material.

Authors: Cassandra E Deering-Rice; Mark E Johansen; Jessica K Roberts; Karen C Thomas; Erin G Romero; Jeewoo Lee; Garold S Yost; John M Veranth; Christopher A Reilly
Journal: Mol Pharmacol Date: 2011-12-09 Impact factor: 4.436

Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.

1. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation.

2. The worker with multiple chemical sensitivities: an overview.

3. Sensory irritation response to inhaled aldehydes after formaldehyde pretreatment.

4. Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation.

5. Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig.

6. A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man.

7. Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1.

8. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity.

9. Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.

10. Capsaicin evokes secretion of nasal fluid and depletes substance P and calcitonin gene-related peptide from the nasal mucosa in the rat.

Review 1. Chemesthesis and the chemical senses as components of a "chemofensor complex".

2. Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material.

3. [Bone marrow hematopoiesis. Evaluation of the myelogram].

Review 4. Chemosensory properties of the trigeminal system.

Review 5. Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures.

6. Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene.

7. Allergic host defences.

8. Intracellular zinc irritates TRPA1.

9. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels.

Review 10. Interaction between TRPA1 and TRPV1: Synergy on pulmonary sensory nerves.