Literature DB >> 1717823

AGP/EBP(LAP) expressed in rat hepatoma cells interacts with multiple promoter sites and is necessary for maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene.

P Williams1, T Ratajczak, S C Lee, G M Ringold.   

Abstract

Transcription of the rat alpha 1-acid glycoprotein (AGP) gene is induced by glucocorticoids. In addition to the glucocorticoid response element which maps to bases -120 to -107, sequences located between bases -106 to -42 have been shown to be necessary for hormone induction. We have previously identified multiple sites of C/EBP interaction with the AGP promoter in the region -106 to -64. In this study, we purify and identify a C/EBP family member, AGP/EBP(LAP), present in the rat hepatoma cell line HTC (JZ.1) which also binds to the C/EBP recognition sites in this region. Mutations in the recognition sites that prevent binding are analyzed, and the results suggest a positive as well as a possible inhibitory role for AGP/EBP(LAP) in the glucocorticoid induction of the gene in HTC (JZ.1) cells.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1717823      PMCID： PMC361476          DOI： 10.1128/mcb.11.10.4959-4965.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  36 in total

1.  Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP.

Authors:  C Roman; J S Platero; J Shuman; K Calame
Journal:  Genes Dev       Date:  1990-08       Impact factor: 11.361

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene.

Authors:  A D Friedman; S L McKnight
Journal:  Genes Dev       Date:  1990-08       Impact factor: 11.361

4.  Dexamethasone regulation of alpha 1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells.

Authors:  H Baumann; G L Firestone; T L Burgess; K W Gross; K R Yamamoto; W A Held
Journal:  J Biol Chem       Date:  1983-01-10       Impact factor: 5.157

5.  Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.

Authors:  M Fried; D M Crothers
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

6.  Biosynthesis and hormone-regulated expression of secretory glycoproteins in rat liver and hepatoma cells. Effect of glucocorticoids and inflammation.

Authors:  H Baumann; W A Held
Journal:  J Biol Chem       Date:  1981-10-10       Impact factor: 5.157

7.  LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

Authors:  P Descombes; M Chojkier; S Lichtsteiner; E Falvey; U Schibler
Journal:  Genes Dev       Date:  1990-09       Impact factor: 11.361

8.  Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family.

Authors:  C J Chang; T T Chen; H Y Lei; D S Chen; S C Lee
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

9.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

10.  Induction of the acute-phase reactant, alpha 1-acid glycoprotein, by glucocorticoids in rat hepatoma cells.

Authors:  J L Vannice; G M Ringold; J W McLean; J M Taylor
Journal:  DNA       Date:  1983
View more
  11 in total

1.  Compilation of vertebrate-encoded transcription factors.

Authors:  S Faisst; S Meyer
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

2.  Analysis of chromatin structure of rat alpha1-acid glycoprotein gene; changes in DNase I hypersensitive sites after thyroid hormone, glucocorticoid hormone and turpentine oil treatment.

Authors:  T Matsukawa; H Kawasaki; M Tanaka; Y Ohba
Journal:  Nucleic Acids Res       Date:  1997-07-01       Impact factor: 16.971

3.  Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor.

Authors:  L H Miau; C J Chang; W H Tsai; S C Lee
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

4.  Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells.

Authors:  R A Ramos; Y Nishio; A C Maiyar; K E Simon; C C Ridder; Y Ge; G L Firestone
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

Review 5.  CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.

Authors:  Cynthia A Zahnow
Journal:  Expert Rev Mol Med       Date:  2009-04-08       Impact factor: 5.600

6.  Involvement of a C/EBP-like protein in the acquisition of responsiveness to glucocorticoid hormones during chick neural retina development.

Authors:  S Ben-Or; S Okret
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

7.  Induction of liver alpha-1 acid glycoprotein gene expression involves both positive and negative transcription factors.

Authors:  Y M Lee; W H Tsai; M Y Lai; D S Chen; S C Lee
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

8.  A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.

Authors:  Y Nishio; H Isshiki; T Kishimoto; S Akira
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

9.  Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression.

Authors:  C J Chang; Y L Chen; S C Lee
Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272

10.  C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements.

Authors:  Lars Grøntved; Sam John; Songjoon Baek; Ying Liu; John R Buckley; Charles Vinson; Greti Aguilera; Gordon L Hager
Journal:  EMBO J       Date:  2013-05-10       Impact factor: 11.598
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.