Literature DB >> 1701020

Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family.

C J Chang1, T T Chen, H Y Lei, D S Chen, S C Lee.   

Abstract

A C/EBP-like transcription factor, AGP/EBP, that binds to three distinct motifs in the 5'-flanking region of alpha 1-acid glycoprotein gene (AGP) has been identified. Here we report the cloning and properties of cDNA corresponding to mouse AGP/EBP. AGP/EBP and C/EBP share 87% amino acid sequence homology in the "leucine zipper" and its associated DNA-binding domains, while their sequences outside these domains and the sizes of their mRNAs are different. Unlike the limited expression of C/EBP in tissues and cells, AGP/EBP appears to be ubiquitously expressed in tissues like lung, spleen, kidney, heart, testis, and liver and cell lines like p388D1, 129P (hepatoma cell line of C3H/HeJ), FO (mouse myeloma), and L929. Antibody against cloned and expressed AGP/EBP which was raised in rabbits could recognize AGP/EBP from nuclear extract of a number of cells and tissues. On the basis of our findings about the structural relationship and the similarity of motif recognition, we propose that a family of C/EBP-like transcription factors exists.

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Year:  1990        PMID： 1701020      PMCID： PMC362942          DOI： 10.1128/mcb.10.12.6642-6653.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  42 in total

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Authors:  K R Prowse; H Baumann
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5.  The role of cis-acting promoter elements in tissue-specific albumin gene expression.

Authors:  P Maire; J Wuarin; U Schibler
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6.  Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP.

Authors:  K G Xanthopoulos; J Mirkovitch; T Decker; C F Kuo; J E Darnell
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8.  Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse.

Authors:  S C Lee; C J Chang; Y M Lee; H Y Lei; M Y Lai; D S Chen
Journal:  DNA       Date:  1989-05

9.  Regulation of major acute-phase plasma proteins by hepatocyte-stimulating factors of human squamous carcinoma cells.

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Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422
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  87 in total

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Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

6.  Production of a monoclonal antibody for C/EBPβ: the subnuclear localization of C/EBPβ in mouse L929 cells.

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8.  C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages.

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Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

9.  High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors.

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10.  Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells.

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