PRIMARY OBJECTIVE: The objective was to examine whether dietary intakes of macronutrients are associated with neuropsychological performance. RESEARCH DESIGN AND METHOD: Study participants were 3960 adults aged 20-59 years, who completed three neuropsychological tests and a 24-hour dietary recall as a part of the Third National Health and Nutrition Examination Survey, 1988-1994. Poor performance was defined as the test score below gender-specific 15th percentile. MAIN OUTCOMES AND RESULTS: While holding the energy percentages from different macronutrients, additional 100 kcal intake of energy was associated with a reduced odds of poor performance on serial digital learning test (OR = 0.98, 95% CI = 0.96, 0.99) and symbol digital substitution test (OR = 0.97, 95% CI = 0.96, 0.99). Compared with equivalent energy from carbohydrates, each 5% of energy from poly-unsaturated fatty acids (PUFA) or total fat was associated with a reduced OR of poor performance on simple reaction time test (PUFA: OR = 0.77, 95% CI = 0.63-0.95 and total fat: OR = 0.93, 95% CI = 0.87, 0.99). Poor global cognition was associated with an additional intake of 100 mg cholesterol (OR = 1.14, 95% CI = 1.05, 1.23). These associations were more salient in men. CONCLUSION: Habitual intake of macronutrients is weakly but significantly associated with cognitive functioning. These relationships are more evident in men.
PRIMARY OBJECTIVE: The objective was to examine whether dietary intakes of macronutrients are associated with neuropsychological performance. RESEARCH DESIGN AND METHOD: Study participants were 3960 adults aged 20-59 years, who completed three neuropsychological tests and a 24-hour dietary recall as a part of the Third National Health and Nutrition Examination Survey, 1988-1994. Poor performance was defined as the test score below gender-specific 15th percentile. MAIN OUTCOMES AND RESULTS: While holding the energy percentages from different macronutrients, additional 100 kcal intake of energy was associated with a reduced odds of poor performance on serial digital learning test (OR = 0.98, 95% CI = 0.96, 0.99) and symbol digital substitution test (OR = 0.97, 95% CI = 0.96, 0.99). Compared with equivalent energy from carbohydrates, each 5% of energy from poly-unsaturated fatty acids (PUFA) or total fat was associated with a reduced OR of poor performance on simple reaction time test (PUFA: OR = 0.77, 95% CI = 0.63-0.95 and total fat: OR = 0.93, 95% CI = 0.87, 0.99). Poor global cognition was associated with an additional intake of 100 mg cholesterol (OR = 1.14, 95% CI = 1.05, 1.23). These associations were more salient in men. CONCLUSION: Habitual intake of macronutrients is weakly but significantly associated with cognitive functioning. These relationships are more evident in men.
Authors: Rosebud O Roberts; Lewis A Roberts; Yonas E Geda; Ruth H Cha; V Shane Pankratz; Helen M O'Connor; David S Knopman; Ronald C Petersen Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472
Authors: Naomi Kakoschke; Ian T Zajac; Jeannie Tay; Natalie D Luscombe-Marsh; Campbell H Thompson; Manny Noakes; Jonathan D Buckley; Gary Wittert; Grant D Brinkworth Journal: Eur J Nutr Date: 2021-05-20 Impact factor: 5.614
Authors: J M Kasper; A J Milton; A E Smith; F Laezza; G Taglialatela; J D Hommel; N Abate Journal: Int J Dev Neurosci Date: 2017-03-31 Impact factor: 2.457