| Literature DB >> 17174306 |
Masato Yugami1, Yasuaki Kabe, Yuki Yamaguchi, Tadashi Wada, Hiroshi Handa.
Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements. However, its role in the regulation of gene expression is as yet poorly understood. In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor alpha mRNA by increasing its stability, possibly through binding to the 3' untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. These results suggest that hnRNP-U enhances the expression of specific genes by regulating mRNA stability.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17174306 PMCID： PMC7130276 DOI： 10.1016/j.febslet.2006.11.062
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124