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Literature DB >> 18815487

Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity.

Deborah J Good¹, Christopher A Coyle, Dana L Fox.

Abstract

In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2008 PMID： 18815487 PMCID： PMC2707263 DOI： 10.1097/JES.0b013e31818782dd

Source DB: PubMed Journal: Exerc Sport Sci Rev ISSN： 0091-6331 Impact factor: 6.230

15 in total

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5. A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity.

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7. Contribution of different mechanisms to compensation for energy restriction in the mouse.

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9. Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene.

Authors: D J Good; F D Porter; K A Mahon; A F Parlow; H Westphal; I R Kirsch
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10. A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children.

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Review 2. Driven to be inactive? The genetics of physical activity.

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Review 4. Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways.

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Review 5. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives.

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6. Leptin signaling regulates hypothalamic expression of nescient helix-loop-helix 2 (Nhlh2) through signal transducer and activator 3 (Stat3).

Authors: Numan Al Rayyan; Jinhua Zhang; Amy S Burnside; Deborah J Good
Journal: Mol Cell Endocrinol Date: 2014-01-29 Impact factor: 4.102