| Literature DB >> 17174271 |
Anna Rosa Sannella1, Luigi Messori, Angela Casini, Franco Francesco Vincieri, Anna Rita Bilia, Giancarlo Majori, Carlo Severini.
Abstract
We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies.Entities:
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Year: 2006 PMID： 17174271 DOI： 10.1016/j.bbrc.2006.12.005
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575