Literature DB >> 1717370

Immune recognition of linear epitopes in peptide fragments of epithelial mucins.

S Briggs1, M R Price, S J Tendler.   

Abstract

Anti-human milk fat globule membrane monoclonal antibodies HMFG-1 and HMFG-2 recognize epitopes within the protein core of human polymorphic epithelial mucin (PEM). These have been identified as PDTR and DTR, respectively. Using the solid phase synthesis of immobilized tetrameric peptides, we have systematically investigated the contribution of each amino acid in the immune recognition of the PDTR domain by the antibodies HMFG-1 and HMFG-2. The findings obtained have been interpreted with respect to the presence of, and requirements for elements of secondary structure, which have been identified in this region of the PEM protein core.

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Year:  1991        PMID： 1717370      PMCID： PMC1384584     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  7 in total

1.  Effect of variations in peptide sequence on anti-human milk fat globule membrane antibody reactions.

Authors:  P X Xing; K Reynolds; G A Pietersz; I F McKenzie
Journal:  Immunology       Date:  1991-02       Impact factor: 7.397

2.  Strategies for epitope analysis using peptide synthesis.

Authors:  H M Geysen; S J Rodda; T J Mason; G Tribbick; P G Schoofs
Journal:  J Immunol Methods       Date:  1987-09-24       Impact factor: 2.303

3.  Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.

Authors:  J Burchell; H Durbin; J Taylor-Papadimitriou
Journal:  J Immunol       Date:  1983-07       Impact factor: 5.422

4.  A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes.

Authors:  J Burchell; J Taylor-Papadimitriou; M Boshell; S Gendler; T Duhig
Journal:  Int J Cancer       Date:  1989-10-15       Impact factor: 7.396

5.  Immunological and structural features of the protein core of human polymorphic epithelial mucin.

Authors:  M R Price; F Hudecz; C O'Sullivan; R W Baldwin; P M Edwards; S J Tendler
Journal:  Mol Immunol       Date:  1990-08       Impact factor: 4.407

6.  Elements of secondary structure in a human epithelial mucin core peptide fragment.

Authors:  S J Tendler
Journal:  Biochem J       Date:  1990-05-01       Impact factor: 3.857

7.  A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.

Authors:  S Gendler; J Taylor-Papadimitriou; T Duhig; J Rothbard; J Burchell
Journal:  J Biol Chem       Date:  1988-09-15       Impact factor: 5.157
  7 in total
  5 in total

1.  Construction of a reshaped HMFG1 antibody and comparison of its fine specificity with that of the parent mouse antibody.

Authors:  M E Verhoeyen; J A Saunders; M R Price; J D Marugg; S Briggs; E L Broderick; S J Eida; A T Mooren; R A Badley
Journal:  Immunology       Date:  1993-03       Impact factor: 7.397

2.  Transmembrane mucins as novel therapeutic targets.

Authors:  Pamela E Constantinou; Brian P Danysh; Neeraja Dharmaraj; Daniel D Carson
Journal:  Expert Rev Endocrinol Metab       Date:  2011-11

3.  Topographical investigations of human ovarian-carcinoma polymorphic epithelial mucin by scanning tunnelling microscopy.

Authors:  C J Roberts; M Sekowski; M C Davies; D E Jackson; M R Price; S J Tendler
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

4.  Androgen-dependent regulation of human MUC1 mucin expression.

Authors:  Stephen Mitchell; Paul Abel; Sanjeev Madaan; James Jeffs; Khurram Chaudhary; Gordon Stamp; El-Nasir Lalani
Journal:  Neoplasia       Date:  2002 Jan-Feb       Impact factor: 5.715

5.  Structural and computational investigations of the conformation of antigenic peptide fragments of human polymorphic epithelial mucin.

Authors:  M J Scanlon; S D Morley; D E Jackson; M R Price; S J Tendler
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857
  5 in total

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