Literature DB >> 1567366

Topographical investigations of human ovarian-carcinoma polymorphic epithelial mucin by scanning tunnelling microscopy.

C J Roberts1, M Sekowski, M C Davies, D E Jackson, M R Price, S J Tendler.   

Abstract

Human polymorphic epithelial mucin is a high-molecular-mass glycoprotein that associates to provide protection to the epithelial-cell surface and may afford the malignant cell a selective advantage for growth. The scanning-tunnelling-microscopy micrographs obtained in the present study identify the purified human ovarian-carcinoma polymorphic epithelial mucin glycoproteins as rod-shaped molecules of mixed length. The dimensions of the individual molecules range from 25 to 45 nm in length and are 3-4 nm in width. The images further suggest that lateral association of the rods occurs.

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Year:  1992        PMID： 1567366      PMCID： PMC1131012          DOI： 10.1042/bj2830181

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  Size and configuration of glycoprotein fragments cleaved from tumor cells by proteolysis.

Authors:  H S Slayter; J F Codington
Journal:  J Biol Chem       Date:  1973-05-25       Impact factor: 5.157

3.  Chemical dissection and negative staining of the bladder luminal membrane.

Authors:  R C Warren; R M Hicks
Journal:  J Ultrastruct Res       Date:  1978-09

4.  Immunological and structural features of the protein core of human polymorphic epithelial mucin.

Authors:  M R Price; F Hudecz; C O'Sullivan; R W Baldwin; P M Edwards; S J Tendler
Journal:  Mol Immunol       Date:  1990-08       Impact factor: 4.407

5.  Monoclonal antibodies to the human mammary gland: III. Monoclonal antibody LICR-LON-M18 identifies impaired expression and excess sialylation of the I(Ma) cell-surface antigen by primary breast carcinoma cells.

Authors:  C S Foster; A M Neville
Journal:  Hum Pathol       Date:  1984-06       Impact factor: 3.466

6.  A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.

Authors:  S Gendler; J Taylor-Papadimitriou; T Duhig; J Rothbard; J Burchell
Journal:  J Biol Chem       Date:  1988-09-15       Impact factor: 5.157

7.  Structural features of human tracheobronchial mucus glycoprotein.

Authors:  M C Rose; W A Voter; C F Brown; B Kaufman
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

8.  Polymorphic epithelial mucin from the sera of advanced breast cancer patients--isolation and partial characterisation.

Authors:  C O'Sullivan; M R Price; R W Baldwin
Journal:  Br J Cancer       Date:  1990-06       Impact factor: 7.640

9.  C595--a monoclonal antibody against the protein core of human urinary epithelial mucin commonly expressed in breast carcinomas.

Authors:  M R Price; J A Pugh; F Hudecz; W Griffiths; E Jacobs; I M Symonds; A J Clarke; W C Chan; R W Baldwin
Journal:  Br J Cancer       Date:  1990-05       Impact factor: 7.640

10.  Structure and function of the Ca antigen.

Authors:  M E Bramwell; V P Bhavanandan; G Wiseman; H Harris
Journal:  Br J Cancer       Date:  1983-08       Impact factor: 7.640
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