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Literature DB >> 17173542

Big roles for small GTPases in the control of directed cell movement.

Abstract

Small GTPases are involved in the control of diverse cellular behaviours, including cellular growth, differentiation and motility. In addition, recent studies have revealed new roles for small GTPases in the regulation of eukaryotic chemotaxis. Efficient chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which shed light on the molecular mechanisms by which small GTPases control directed cell migration.

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Year: 2007 PMID： 17173542 PMCID： PMC1820805 DOI： 10.1042/BJ20061432

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

211 in total

1. Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction.

Authors: D B Foster; L H Shen; J Kelly; P Thibault; J E Van Eyk; A S Mak
Journal: J Biol Chem Date: 2000-01-21 Impact factor: 5.157

2. WAVE2 is required for directed cell migration and cardiovascular development.

Authors: Daisuke Yamazaki; Shiro Suetsugu; Hiroaki Miki; Yuki Kataoka; Shin-Ichi Nishikawa; Takashi Fujiwara; Nobuaki Yoshida; Tadaomi Takenawa
Journal: Nature Date: 2003-07-24 Impact factor: 49.962

3. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.

Authors: Junji Yamauchi; Yuki Miyamoto; Akito Tanoue; Eric M Shooter; Jonah R Chan
Journal: Proc Natl Acad Sci U S A Date: 2005-10-03 Impact factor: 11.205

4. Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.

Authors: R Kozma; S Sarner; S Ahmed; L Lim
Journal: Mol Cell Biol Date: 1997-03 Impact factor: 4.272

5. Computer-assisted analysis of filopod formation and the role of myosin II heavy chain phosphorylation in Dictyostelium.

Authors: Paul J Heid; Jeremy Geiger; Deborah Wessels; Edward Voss; David R Soll
Journal: J Cell Sci Date: 2005-04-26 Impact factor: 5.285

6. The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.

Authors: J Faix; C Clougherty; A Konzok; U Mintert; J Murphy; R Albrecht; B Mühlbauer; J Kuhlmann
Journal: J Cell Sci Date: 1998-10 Impact factor: 5.285

7. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

Authors: G C Zondag; E E Evers; J P ten Klooster; L Janssen; R A van der Kammen; J G Collard
Journal: J Cell Biol Date: 2000-05-15 Impact factor: 10.539

Review 8. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.

Authors: T Takenawa; H Miki
Journal: J Cell Sci Date: 2001-05 Impact factor: 5.285

9. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.

Authors: R Insall; A Kuspa; P J Lilly; G Shaulsky; L R Levin; W F Loomis; P Devreotes
Journal: J Cell Biol Date: 1994-09 Impact factor: 10.539

10. The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium.

Authors: L Wu; R Valkema; P J Van Haastert; P N Devreotes
Journal: J Cell Biol Date: 1995-06 Impact factor: 10.539

78 in total

1. HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.

Authors: Xiaoyu Jiang; Xiaoqing Lu; George McNamara; Xiaofei Liu; Elena Cubedo; Kristopher A Sarosiek; Isidro Sánchez-García; David M Helfman; Izidore S Lossos
Journal: Blood Date: 2010-09-15 Impact factor: 22.113

Big roles for small GTPases in the control of directed cell movement.

1. Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction.

2. WAVE2 is required for directed cell migration and cardiovascular development.

3. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.

4. Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.

5. Computer-assisted analysis of filopod formation and the role of myosin II heavy chain phosphorylation in Dictyostelium.

6. The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.

7. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

Review 8. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.

9. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.

10. The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium.

1. HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.

2. Cell polarity/motility in bacteria: closer to eukaryotes than expected?

3. External and internal constraints on eukaryotic chemotaxis.

4. Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1.

Review 5. Gliding motility revisited: how do the myxobacteria move without flagella?

6. RhoA regulates dendrite branching in hippocampal neurons by decreasing cypin protein levels.

7. Wave-pinning and cell polarity from a bistable reaction-diffusion system.

8. Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry.

Review 9. Cell motility in cancer invasion and metastasis: insights from simple model organisms.

10. Bacterial motility complexes require the actin-like protein, MreB and the Ras homologue, MglA.