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Literature DB >> 1716695

The flavivirus envelope protein E: isolation of a soluble form from tick-borne encephalitis virus and its crystallization.

F X Heinz¹, C W Mandl, H Holzmann, C Kunz, B A Harris, F Rey, S C Harrison.

Abstract

By the use of limited trypsin digestion of purified virions, we generated a membrane anchor-free and crystallizable form of the tick-borne encephalitis virus envelope glycoprotein E. It retained its reactivity with a panel of monoclonal antibodies, and only subtle structural differences from the native protein E were recognized. Treatment with the bifunctional cross-linker dimethylsuberimidate resulted in the formation of a dimer. Crystallization experiments yielded hexagonal rod-shaped crystals suitable for X-ray diffraction analysis.

Entities: Chemical Species

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Year: 1991 PMID： 1716695 PMCID： PMC249068

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

28 in total

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Authors: C W Mandl; F X Heinz; C Kunz
Journal: Virology Date: 1988-09 Impact factor: 3.616

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Authors: F X Heinz; C Kunz
Journal: J Gen Virol Date: 1980-02 Impact factor: 3.891

28 in total

1. Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E.

Authors: S L Allison; K Stiasny; K Stadler; C W Mandl; F X Heinz
Journal: J Virol Date: 1999-07 Impact factor: 5.103

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Authors: Richard J Kuhn; Wei Zhang; Michael G Rossmann; Sergei V Pletnev; Jeroen Corver; Edith Lenches; Christopher T Jones; Suchetana Mukhopadhyay; Paul R Chipman; Ellen G Strauss; Timothy S Baker; James H Strauss
Journal: Cell Date: 2002-03-08 Impact factor: 41.582

3. Visualization of membrane protein domains by cryo-electron microscopy of dengue virus.

Authors: Wei Zhang; Paul R Chipman; Jeroen Corver; Peter R Johnson; Ying Zhang; Suchetana Mukhopadhyay; Timothy S Baker; James H Strauss; Michael G Rossmann; Richard J Kuhn
Journal: Nat Struct Biol Date: 2003-10-05

4. Structures of immature flavivirus particles.

Authors: Ying Zhang; Jeroen Corver; Paul R Chipman; Wei Zhang; Sergei V Pletnev; Dagmar Sedlak; Timothy S Baker; James H Strauss; Richard J Kuhn; Michael G Rossmann
Journal: EMBO J Date: 2003-06-02 Impact factor: 11.598

5. Impact of quaternary organization on the antigenic structure of the tick-borne encephalitis virus envelope glycoprotein E.

Authors: Stefan Kiermayr; Karin Stiasny; Franz X Heinz
Journal: J Virol Date: 2009-06-24 Impact factor: 5.103

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Authors: Rushika Perera; Mansoora Khaliq; Richard J Kuhn
Journal: Antiviral Res Date: 2008-06-11 Impact factor: 5.970

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Journal: J Virol Date: 1999-03 Impact factor: 5.103

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Authors: K Stiasny; S L Allison; A Marchler-Bauer; C Kunz; F X Heinz
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10. Structural optimization and de novo design of dengue virus entry inhibitory peptides.

Authors: Joshua M Costin; Ekachai Jenwitheesuk; Shee-Mei Lok; Elizabeth Hunsperger; Kelly A Conrads; Krystal A Fontaine; Craig R Rees; Michael G Rossmann; Sharon Isern; Ram Samudrala; Scott F Michael
Journal: PLoS Negl Trop Dis Date: 2010-06-22