| Literature DB >> 17165901 |
Crystal G Bashore1, Michael G Vetelino, Michael C Wirtz, Paige R Brooks, Heather N Frost, Ruth E McDermott, David C Whritenour, John A Ragan, Jennifer L Rutherford, Teresa W Makowski, Steven J Brenek, Jotham W Coe.
Abstract
[Structure: see text] The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and an enantioselective cyclization to establish a compound with the key [3.2.1]-bicyclic core, 29.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17165901 DOI： 10.1021/ol0623062
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005