Literature DB >> 171653

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.

D S Newcombe, C P Ciosek, Y Ishikawa, J V Fahey.   

Abstract

The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.

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Year:  1975        PMID： 171653      PMCID： PMC432933          DOI： 10.1073/pnas.72.8.3124

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.

Authors:  J Otten; G S Johnson; I Pastan
Journal:  Biochem Biophys Res Commun       Date:  1971-09       Impact factor: 3.575

3.  Formation and release of a hormone antagonist by rat adipocytes.

Authors:  R J Ho; E W Sutherland
Journal:  J Biol Chem       Date:  1971-11-25       Impact factor: 5.157

4.  Restoration of glucagon responsiveness of solubilized myocardial adenyl cyclase by phosphatidylserine.

Authors:  G S Levey
Journal:  Biochem Biophys Res Commun       Date:  1971-04-02       Impact factor: 3.575

5.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain.

Authors:  W J Thompson; M M Appleman
Journal:  Biochemistry       Date:  1971-01-19       Impact factor: 3.162

6.  Cyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells.

Authors:  J P Schwartz; J V Passonneau
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

7.  An effect of insulin on adipose-tissue adenosine 3':5'-cyclic monophosphate phosphodiesterase.

Authors:  E G Loten; J G Sneyd
Journal:  Biochem J       Date:  1970-11       Impact factor: 3.857

8.  A protein binding assay for adenosine 3':5'-cyclic monophosphate.

Authors:  A G Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

9.  Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture-enzyme kinetics-prostaglandin homologues).

Authors:  V Maganiello; M Vaughan
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

10.  Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 ).

Authors:  M D'Armiento; G S Johnson; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205
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  17 in total

1.  Evidence for internalization of the recognition site of beta-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol.

Authors:  D M Chuang; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

2.  Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.

Authors:  C Mukherjee; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

Review 3.  Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation.

Authors:  D R Sibley; R J Lefkowitz
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

4.  Rheumatoid synovial cell hormone responses modulated by cell-cell interactions.

Authors:  S R Goldring; J M Dayer; S M Krane
Journal:  Inflammation       Date:  1984-03       Impact factor: 4.092

5.  Human synovial fibroblasts: the relationships between cyclic AMP, bradykinin, and prostaglandins.

Authors:  J V Fahey; C P Ciosek; D S Newcombe
Journal:  Agents Actions       Date:  1977-07

6.  Factors modulating the response of a porcine renal tubular cell line to calcitonin and antidiuretic hormone.

Authors:  J F Héron; J M Dayer; S R Goldring; S M Krane
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

7.  Rheumatoid synovium: its proliferation, heterogeneity and polarization.

Authors:  E D Harris
Journal:  West J Med       Date:  1977-09

8.  Misoprostol, a prostaglandin E1 analogue, inhibits basic calcium phosphate crystal-induced mitogenesis and collagenase accumulation in human fibroblasts.

Authors:  G M McCarthy; P G Mitchell; H S Cheung
Journal:  Calcif Tissue Int       Date:  1993-06       Impact factor: 4.333

9.  Modulation of collagen production by fibroblasts. Effects of chronic exposure to agonists that increase intracellular cyclic AMP.

Authors:  L E Saltzman; J Moss; R A Berg; B Hom; R G Crystal
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

10.  Desensitization of prostacyclin receptors in a neuronal hybrid cell line.

Authors:  I A Blair; P J Leigh; J MacDermot
Journal:  Br J Pharmacol       Date:  1982-09       Impact factor: 8.739
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