Literature DB >> 17163756

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.

Gabriela Chiosis1, Len Neckers.   

Abstract

Two recent papers attempt to solve both the tumor selectivity and the in vivo tumor accumulation profiles seen with some Hsp90 inhibitors. They spotlight the higher affinity of ansamycins' hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins' tumor selectivity.

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Year:  2006        PMID： 17163756     DOI： 10.1021/cb600224w

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  49 in total

Review 1.  Post-translational modifications of Hsp90 and translating the chaperone code.

Authors:  Sarah J Backe; Rebecca A Sager; Mark R Woodford; Alan M Makedon; Mehdi Mollapour
Journal:  J Biol Chem       Date:  2020-06-11       Impact factor: 5.157

2.  A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.

Authors:  Philip Reigan; David Siegel; Wenchang Guo; David Ross
Journal:  Mol Pharmacol       Date:  2011-02-01       Impact factor: 4.436

Review 3.  Hsp90--from signal transduction to cell transformation.

Authors:  Mark A Brown; Li Zhu; Christian Schmidt; Philip W Tucker
Journal:  Biochem Biophys Res Commun       Date:  2007-08-20       Impact factor: 3.575

4.  Visualizing the twists and turns of a molecular chaperone.

Authors:  Len Neckers; Shinji Tsutsumi; Mehdi Mollapour
Journal:  Nat Struct Mol Biol       Date:  2009-03       Impact factor: 15.369

Review 5.  Functions of the Hsp90 chaperone system: lifting client proteins to new heights.

Authors:  Julia M Eckl; Klaus Richter
Journal:  Int J Biochem Mol Biol       Date:  2013-12-15

Review 6.  Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.

Authors:  Gaurav Garg; Anuj Khandelwal; Brian S J Blagg
Journal:  Adv Cancer Res       Date:  2016-02-10       Impact factor: 6.242

7.  Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.

Authors:  Sofia Barluenga; Cuihua Wang; Jean-Gonzague Fontaine; Kaïss Aouadi; Kristin Beebe; Shinji Tsutsumi; Len Neckers; Nicolas Winssinger
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 8.  The HSP90 chaperone machinery.

Authors:  Florian H Schopf; Maximilian M Biebl; Johannes Buchner
Journal:  Nat Rev Mol Cell Biol       Date:  2017-04-21       Impact factor: 94.444

Review 9.  New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.

Authors:  Yanyan Li; Tao Zhang; Steven J Schwartz; Duxin Sun
Journal:  Drug Resist Updat       Date:  2009 Feb-Apr       Impact factor: 18.500

10.  HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.

Authors:  Bin Peng; Limin Xu; Fanfan Cao; Tingxuan Wei; Chunxin Yang; Georges Uzan; Denghai Zhang
Journal:  Mol Cancer       Date:  2010-04-16       Impact factor: 27.401
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