Literature DB >> 17163754

Chemical modifications rescue off-target effects of RNAi.

Ola Snøve1, John J Rossi.   

Abstract

RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.

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Year:  2006        PMID： 17163754     DOI： 10.1021/cb6002256

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  8 in total

Review 1.  Chemical modification: the key to clinical application of RNA interference?

Authors:  David R Corey
Journal:  J Clin Invest       Date:  2007-12       Impact factor: 14.808

2.  Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum.

Authors:  John A H Hoerter; Nils G Walter
Journal:  RNA       Date:  2007-09-05       Impact factor: 4.942

3.  Advances in Systemic siRNA Delivery.

Authors:  Qixin Leng; Martin C Woodle; Patrick Y Lu; A James Mixson
Journal:  Drugs Future       Date:  2009-09       Impact factor: 0.148

Review 4.  RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?

Authors:  Sandesh Subramanya; Sang-Soo Kim; N Manjunath; Premlata Shankar
Journal:  Expert Opin Biol Ther       Date:  2010-02       Impact factor: 4.388

5.  Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.

Authors:  Dale C Guenther; Shohei Mori; Shigeo Matsuda; Jason A Gilbert; Jennifer L S Willoughby; Sarah Hyde; Anna Bisbe; Yongfeng Jiang; Saket Agarwal; Mimouna Madaoui; Maja M Janas; Klaus Charisse; Martin A Maier; Martin Egli; Muthiah Manoharan
Journal:  J Am Chem Soc       Date:  2022-08-03       Impact factor: 16.383

6.  Suppression of Gq Function Using Intra-Pipette Delivery of shRNA during Extracellular Recording in the Ventral Tegmental Area.

Authors:  Sudarat Nimitvilai; Devinder S Arora; Maureen A McElvain; Mark S Brodie
Journal:  Front Cell Neurosci       Date:  2013-02-12       Impact factor: 5.505

Review 7.  Modulating the expression of disease genes with RNA-based therapy.

Authors:  Matthew Wood; Haifang Yin; Graham McClorey
Journal:  PLoS Genet       Date:  2007-06       Impact factor: 5.917

Review 8.  Maintaining the silence: reflections on long-term RNAi.

Authors:  Koen Raemdonck; Roosmarijn E Vandenbroucke; Joseph Demeester; Niek N Sanders; Stefaan C De Smedt
Journal:  Drug Discov Today       Date:  2008-08-07       Impact factor: 7.851
  8 in total

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