| Literature DB >> 17163674 |
Congcong He1, Daniel J Klionsky.
Abstract
Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.Entities:
Mesh：
Year: 2006 PMID： 17163674 DOI： 10.1021/cb600182h
Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100