Literature DB >> 17161906

Variable RXR requirements for thyroid hormone responsiveness of endogenous genes.

Ericka M Diallo1, Kenneth G Wilhelm, Deborah L Thompson, Ronald J Koenig.   

Abstract

Thyroid hormone receptors heterodimerize with retinoid X receptors in vitro and it is widely assumed that these heterodimers mediate the T3 induction of target genes. However, the importance of RXR for the T3 induction of endogenous genes has not been assessed. We used cDNA microarrays to identify 54 genes induced by T3 in Neuro2a cells that express thyroid hormone receptor beta. RNA interference-mediated knock down of endogenous RXRs showed that these genes vary from being highly dependent on RXR for T3 induction to being independent of RXR. Thus, the availability of RXR may differentially regulate the T3 induction of subsets of genes within a cell. Furthermore, coregulatory proteins that preferentially interact with TR homodimers or RXR-TR heterodimers may further expand the range of T3 response for genes within the same cell.

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Year:  2006        PMID： 17161906      PMCID： PMC1828278          DOI： 10.1016/j.mce.2006.11.004

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  18 in total

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Authors:  D P Olson; R J Koenig
Journal:  J Biol Chem       Date:  1997-04-11       Impact factor: 5.157

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Journal:  Mol Endocrinol       Date:  1992-10

4.  Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

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Journal:  Genes Dev       Date:  1993-07       Impact factor: 11.361

5.  Overexpression of the beta 1 thyroid receptor induces differentiation in neuro-2a cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-29       Impact factor: 11.205

6.  Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.

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Journal:  Nature       Date:  1992-08-13       Impact factor: 49.962

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Authors:  J S Subauste; R W Katz; R J Koenig
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8.  Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205

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Journal:  Nature       Date:  1992-01-30       Impact factor: 49.962
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  8 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-21       Impact factor: 11.205

Review 2.  Regulation of photoreceptor gene expression by Crx-associated transcription factor network.

Authors:  Anne K Hennig; Guang-Hua Peng; Shiming Chen
Journal:  Brain Res       Date:  2007-06-30       Impact factor: 3.252

3.  Mediator subunit MED1 modulates intranuclear dynamics of the thyroid hormone receptor.

Authors:  Matthew R Femia; Rochelle M Evans; Jibo Zhang; Xiaopeng Sun; Caroline J Lebegue; Vincent R Roggero; Lizabeth A Allison
Journal:  J Cell Biochem       Date:  2019-11-06       Impact factor: 4.429

4.  Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.

Authors:  Julie M Quach; Emma C Walker; Elizabeth Allan; Melissa Solano; Atsushi Yokoyama; Shigeaki Kato; Natalie A Sims; Matthew T Gillespie; T John Martin
Journal:  J Biol Chem       Date:  2010-12-01       Impact factor: 5.157

Review 5.  Thyroid hormone receptor localization in target tissues.

Authors:  Cyril S Anyetei-Anum; Vincent R Roggero; Lizabeth A Allison
Journal:  J Endocrinol       Date:  2018-02-12       Impact factor: 4.286

6.  Mislocalization of Cancer-associated Thyroid Hormone Receptor Mutants.

Authors:  Michael S Salomon; S Harshini Malapati; Jerry O' Dwyer; Carolina Lopez Silva; Cheyenne C Williams; Michelle C Barbeau; Delbert Yip; Paige Punzalan; Veronica L Nagle; Shantá D Hinton; Vincent R Roggero; Lizabeth A Allison
Journal:  Nucl Receptor Res       Date:  2020

7.  DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified.

Authors:  Theresa Q Phan; Margaret M Jow; Martin L Privalsky
Journal:  Mol Cell Endocrinol       Date:  2009-11-27       Impact factor: 4.102

8.  Coactivator recruitment is enhanced by thyroid hormone receptor trimers.

Authors:  Brenda J Mengeling; Sangho Lee; Martin L Privalsky
Journal:  Mol Cell Endocrinol       Date:  2007-10-06       Impact factor: 4.102
  8 in total

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