| Literature DB >> 17160971 |
Izzettin Hatip-Al-Khatib1, Funda Bölukbaşi Hatip, Yoshitaka Yoshimitsu, Katsunori Iwasaki, Nobuaki Egashira, An-Xin Liu, Kenichi Mishima, Michihiro Fujiwara.
Abstract
The effects of Toki-shakuyaku-san (TSS) ingredients on acetylcholine (ACh) release in the dorsal hippocampus (DH) were investigated in intact and twice-repeated ischemic rats using in vivo microdialysis-HPLC. Moreover, the effect of TSS on blood flow was investigated in intact rats using laser Doppler flowmetry. TSS at 300 mg/kg p.o. increased ACh and blood flow after 40 min in intact rats. TSS also increased ACh in ischemic rats but to a lesser extent than in intact rats. These results could suggest that TSS-increased ACh and blood flow in DH may contribute in the cognition improving property of TSS.Entities:
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Year: 2007 PMID： 17160971 DOI： 10.1002/ptr.2050
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878