OBJECTIVE: To investigate the effects of occupational activity and leisure time activity on incident colon cancer risk in a Danish middle-aged population. METHODS: In the cohort, Diet, Cancer and Health, which included 28,356 women and 26,122 men aged 50-64 years at baseline, 140 women and 157 men were diagnosed with colon cancer from 1993 to 2003. The associations between occupational and leisure time activity in terms of a MET-score and the single activities, sports, cycling, walking, gardening, housework and do-it-yourself work, and incident colon cancer were investigated. Leisure time activity was investigated in two ways using the Cox proportional hazards model: by comparison of active versus non-active and by investigating a possible dose-response relationship while allowing a separate association for non-active individuals. RESULTS: No associations were found between risk of colon cancer and occupational activity, MET-hours per week of total leisure time activity, residuals from a regression of each activity on the total MET-hours or the time spent on any of the six types of leisure time activities. However, a borderline significant association was found with the number of activities in which the participants were active. For each additional activity IRR = 0.87 (0.76-1.00) for women and IRR = 0.88 (0.78-1.00) for men. CONCLUSION: Our data do not support the evidence of an inverse association between colon cancer risk and occupational activity or leisure time activity, but avoiding a sedentary lifestyle by participating in different activities may reduce colon cancer risk.
OBJECTIVE: To investigate the effects of occupational activity and leisure time activity on incident colon cancer risk in a Danish middle-aged population. METHODS: In the cohort, Diet, Cancer and Health, which included 28,356 women and 26,122 men aged 50-64 years at baseline, 140 women and 157 men were diagnosed with colon cancer from 1993 to 2003. The associations between occupational and leisure time activity in terms of a MET-score and the single activities, sports, cycling, walking, gardening, housework and do-it-yourself work, and incident colon cancer were investigated. Leisure time activity was investigated in two ways using the Cox proportional hazards model: by comparison of active versus non-active and by investigating a possible dose-response relationship while allowing a separate association for non-active individuals. RESULTS: No associations were found between risk of colon cancer and occupational activity, MET-hours per week of total leisure time activity, residuals from a regression of each activity on the total MET-hours or the time spent on any of the six types of leisure time activities. However, a borderline significant association was found with the number of activities in which the participants were active. For each additional activity IRR = 0.87 (0.76-1.00) for women and IRR = 0.88 (0.78-1.00) for men. CONCLUSION: Our data do not support the evidence of an inverse association between colon cancer risk and occupational activity or leisure time activity, but avoiding a sedentary lifestyle by participating in different activities may reduce colon cancer risk.
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Authors: Lise Geisler Andersen; Lars Angquist; Michael Gamborg; Liisa Byberg; Calle Bengtsson; Dexter Canoy; Johan G Eriksson; Marit Eriksson; Marjo-Riitta Järvelin; Lauren Lissner; Tom I Nilsen; Merete Osler; Kim Overvad; Finn Rasmussen; Minna K Salonen; Lene Schack-Nielsen; Tuija H Tammelin; Tomi-Pekka Tuomainen; Thorkild I A Sørensen; Jennifer L Baker Journal: PLoS One Date: 2009-12-16 Impact factor: 3.240