Literature DB >> 17159925

Why is cancer drug discovery so difficult?

Alexander Kamb1, Susan Wee, Christoph Lengauer.   

Abstract

Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.

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Year:  2006        PMID: 17159925     DOI: 10.1038/nrd2155

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  97 in total

Review 1.  Tumor-targeting drug delivery of new-generation taxoids.

Authors:  Iwao Ojima; Edison S Zuniga; William T Berger; Joshua D Seitz
Journal:  Future Med Chem       Date:  2012-01       Impact factor: 3.808

Review 2.  Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

Authors:  Bokyung Sung; Sahdeo Prasad; Vivek R Yadav; Bharat B Aggarwal
Journal:  Nutr Cancer       Date:  2011-12-09       Impact factor: 2.900

Review 3.  Mechanisms of drug combinations: interaction and network perspectives.

Authors:  Jia Jia; Feng Zhu; Xiaohua Ma; Zhiwei Cao; Zhiwei W Cao; Yixue Li; Yixue X Li; Yu Zong Chen
Journal:  Nat Rev Drug Discov       Date:  2009-02       Impact factor: 84.694

4.  Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.

Authors:  Sami Osman; Brian J Albert; Yanping Wang; Miaosheng Li; Nancy L Czaicki; Kazunori Koide
Journal:  Chemistry       Date:  2010-11-19       Impact factor: 5.236

Review 5.  Integration and analysis of genome-scale data from gliomas.

Authors:  Gregory Riddick; Howard A Fine
Journal:  Nat Rev Neurol       Date:  2011-07-05       Impact factor: 42.937

6.  High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer.

Authors:  Feng Shan; David A Close; Daniel P Camarco; Paul A Johnston
Journal:  Assay Drug Dev Technol       Date:  2017-12-07       Impact factor: 1.738

Review 7.  Heterogeneity of glycolysis in cancers and therapeutic opportunities.

Authors:  Marc O Warmoes; Jason W Locasale
Journal:  Biochem Pharmacol       Date:  2014-08-02       Impact factor: 5.858

Review 8.  Taxane anticancer agents: a patent perspective.

Authors:  Iwao Ojima; Brendan Lichtenthal; Siyeon Lee; Changwei Wang; Xin Wang
Journal:  Expert Opin Ther Pat       Date:  2015-12-10       Impact factor: 6.674

Review 9.  Comparative oncology today.

Authors:  Melissa C Paoloni; Chand Khanna
Journal:  Vet Clin North Am Small Anim Pract       Date:  2007-11       Impact factor: 2.093

10.  Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities.

Authors:  Rui-Ru Ji; Heshani de Silva; Yisheng Jin; Robert E Bruccoleri; Jian Cao; Aiqing He; Wenjun Huang; Paul S Kayne; Isaac M Neuhaus; Karl-Heinz Ott; Becky Penhallow; Mark I Cockett; Michael G Neubauer; Nathan O Siemers; Petra Ross-Macdonald
Journal:  PLoS Comput Biol       Date:  2009-09-18       Impact factor: 4.475

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