| Literature DB >> 24210837 |
Stephen Correia1, Ronald Cohen, Assawin Gongvatana, Skye Ross, James Olchowski, Kathryn Devlin, Karen Tashima, Bradford Navia, Suzanne Delamonte.
Abstract
Chronic systemic immune activation and inflammatory processes have been linked to brain dysfunction in medically stable HIV-infected people. We investigated the association between verbal memory performance and plasma concentrations of 13 cytokines measured using multiplexed bead array immunoassay in 74 HIV-seropositive individuals and 50 HIV-seronegative controls. Memory performance was positively related to levels of IL-8 and IFN-γ, and negatively related to IL-10 and IL-18 and to hepatitis C infection. Memory performance was not significantly related to HIV disease markers. The results indicate the importance of systemic immune and inflammatory markers to neurocognitive function in chronic and stable HIV disease.Entities:
Keywords: CART; Cytokines; HIV; HIV clinical markers; Hepatitis C; Memory
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Year: 2013 PMID: 24210837 PMCID: PMC4422333 DOI: 10.1016/j.jneuroim.2013.09.005
Source DB: PubMed Journal: J Neuroimmunol ISSN: 0165-5728 Impact factor: 3.478