Literature DB >> 17158733

Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase.

John R Erb-Downward1, Gary B Huffnagle.   

Abstract

Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E(2) from Cryptococcus neoformans. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.

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Year:  2006        PMID： 17158733      PMCID： PMC1797952          DOI： 10.1128/EC.00336-06

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  17 in total

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Authors:  M C Noverr; S M Phare; G B Toews; M J Coffey; G B Huffnagle
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

5.  Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production.

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Journal:  Infect Immun       Date:  2003-03       Impact factor: 3.441

6.  Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells.

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7.  Phospholipase B activity enhances adhesion of Cryptococcus neoformans to a human lung epithelial cell line.

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  19 in total

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Journal:  J Microbiol       Date:  2016-02-27       Impact factor: 3.422

Review 4.  Prostaglandin E2 as a Regulator of Immunity to Pathogens.

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6.  Lipids Affect the Cryptococcus neoformans-Macrophage Interaction and Promote Nonlytic Exocytosis.

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7.  Peroxisomal and mitochondrial β-oxidation pathways influence the virulence of the pathogenic fungus Cryptococcus neoformans.

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Journal:  Eukaryot Cell       Date:  2012-06-15

Review 8.  Paradoxical roles of alveolar macrophages in the host response to Cryptococcus neoformans.

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Review 9.  Lipid signaling in pathogenic fungi.

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10.  The role of laccase in prostaglandin production by Cryptococcus neoformans.

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