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Literature DB >> 17158669

Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.

Hirokazu Suzuki¹, Yasuo Ohnishi, Sueharu Horinouchi.

Abstract

An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabolism of xenobiotic compounds.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2006 PMID： 17158669 PMCID： PMC1855759 DOI： 10.1128/JB.01708-06

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

26 in total

1. Structure of arylamine N-acetyltransferase reveals a catalytic triad.

Authors: J C Sinclair; J Sandy; R Delgoda; E Sim; M E Noble
Journal: Nat Struct Biol Date: 2000-07

2. Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid.

Authors: C Deloménie; S Fouix; S Longuemaux; N Brahimi; C Bizet; B Picard; E Denamur; J M Dupret
Journal: J Bacteriol Date: 2001-06 Impact factor: 3.490

3. Eubacterial arylamine N-acetyltransferases - identification and comparison of 18 members of the protein family with conserved active site cysteine, histidine and aspartate residues.

Authors: Mark Payton; Adeel Mushtaq; Tin-Wein Yu; Ling-Juan Wu; John Sinclair; Edith Sim
Journal: Microbiology (Reading) Date: 2001-05 Impact factor: 2.777

4. An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.

Authors: Edward W Brooke; Stephen G Davies; Andrew W Mulvaney; Frédérique Pompeo; Edith Sim; Richard J Vickers
Journal: Bioorg Med Chem Date: 2003-04-03 Impact factor: 3.641

Review 5. A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus.

Authors: Sueharu Horinouchi
Journal: Front Biosci Date: 2002-10-01

6. Genetic analysis of A-factor synthesis in Streptomyces coelicolor A3(2) and Streptomyces griseus.

Authors: O Hara; S Horinouchi; T Uozumi; T Beppu
Journal: J Gen Microbiol Date: 1983-09

Review 7. Arylamine N-acetyltransferases: a pharmacogenomic approach to drug metabolism and endogenous function.

Authors: E Sim; K Pinter; A Mushtaq; A Upton; J Sandy; S Bhakta; M Noble
Journal: Biochem Soc Trans Date: 2003-06 Impact factor: 5.407

8. Mechanism of activation of proximate mutagens in Ames' tester strains: the acetyl-CoA dependent enzyme in Salmonella typhimurium TA98 deficient in TA98/1,8-DNP6 catalyzes DNA-binding as the cause of mutagenicity.

Authors: K Saito; Y Yamazoe; T Kamataki; R Kato
Journal: Biochem Biophys Res Commun Date: 1983-10-14 Impact factor: 3.575

9. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.

Authors: Tin-Wein Yu; Linquan Bai; Dorothee Clade; Dietmar Hoffmann; Sabine Toelzer; Khue Q Trinh; Jun Xu; Steven J Moss; Eckhard Leistner; Heinz G Floss
Journal: Proc Natl Acad Sci U S A Date: 2002-06-11 Impact factor: 11.205

10. Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target.

Authors: Sanjib Bhakta; Gurdyal S Besra; Anna M Upton; Tanya Parish; Carolyn Sholto-Douglas-Vernon; Kevin J C Gibson; Stuart Knutton; Siamon Gordon; Rosangela P DaSilva; Matthew C Anderton; Edith Sim
Journal: J Exp Med Date: 2004-04-26 Impact factor: 14.307

8 in total

1. Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.

Authors: Elizabeth Fullam; Akane Kawamura; Helen Wilkinson; Areej Abuhammad; Isaac Westwood; Edith Sim
Journal: Protein J Date: 2009-08 Impact factor: 2.371

2. Microbial biotransformation of aryl sulfanylpentafluorides.

Authors: Emma Kavanagh; Michael Winn; Cliona Nic Gabhann; Neil K O'Connor; Petr Beier; Cormac D Murphy
Journal: Environ Sci Pollut Res Int Date: 2013-07-20 Impact factor: 4.223

3. Identification of the enzyme responsible for N-acetylation of norfloxacin by Microbacterium sp. Strain 4N2-2.

Authors: Dae-Wi Kim; Jinhui Feng; Huizhong Chen; Ohgew Kweon; Yuan Gao; Li-Rong Yu; Vanessa J Burrowes; John B Sutherland
Journal: Appl Environ Microbiol Date: 2012-10-26 Impact factor: 4.792

4. The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog.

Authors: Vasiliki Garefalaki; Evanthia Kontomina; Charalambos Ioannidis; Olga Savvidou; Christina Vagena-Pantoula; Maria-Giusy Papavergi; Ioannis Olbasalis; Dionysios Patriarcheas; Konstantina C Fylaktakidou; Tamás Felföldi; Károly Márialigeti; Giannoulis Fakis; Sotiria Boukouvala
Journal: World J Microbiol Biotechnol Date: 2019-10-31 Impact factor: 3.312

5. Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66.

Authors: Shuqi Guo; Yunxiao Wang; Wei Wang; Hongbo Hu; Xuehong Zhang
Journal: Microb Cell Fact Date: 2020-05-19 Impact factor: 5.328