| Literature DB >> 17158055 |
Filippo Lodi1, Silvia Trespidi, Donato Di Pierro, Mario Marengo, Mohsen Farsad, Stefano Fanti, Roberto Franchi, Stefano Boschi.
Abstract
A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. This module configuration was applied to the solid-phase synthesis of N-[11C]methyl-choline ([11C]choline) and L-(S-methyl-[11C])methionine ([11C]methionine), using [11C]CH(3)I as methylating agent, as well as to the synthesis of [11C]acetate by [11C]carboxylation with [11C]CO2 of methylmagnesium chloride with high and reproducible radiochemical yields in short reaction time, demonstrating to be a fast and reliable tool for the production of these [11C]radiopharmaceuticals for clinical use.Entities:
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Year: 2006 PMID： 17158055 DOI： 10.1016/j.apradiso.2006.10.011
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513