Literature DB >> 17157014

Inhibitors of the FEZ-1 metallo-beta-lactamase.

Benoît M R Liénard1, Louise E Horsfall, Moreno Galleni, Jean-Marie Frère, Christopher J Schofield.   

Abstract

Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of 6.1+/-0.7microM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.

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Year:  2006        PMID： 17157014     DOI： 10.1016/j.bmcl.2006.11.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?

Authors:  Peter Oelschlaeger; Ni Ai; Kevin T Duprez; William J Welsh; Jeffrey H Toney
Journal:  J Med Chem       Date:  2010-04-22       Impact factor: 7.446

2.  Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Authors:  Peter Šilhár; Nicholas R Silvaggi; Sabine Pellett; Kateřina Čapková; Eric A Johnson; Karen N Allen; Kim D Janda
Journal:  Bioorg Med Chem       Date:  2012-12-20       Impact factor: 3.641

3.  New β-phospholactam as a carbapenem transition state analog: Synthesis of a broad-spectrum inhibitor of metallo-β-lactamases.

Authors:  Ke-Wu Yang; Lei Feng; Shao-Kang Yang; Mahesh Aitha; Alecander E LaCuran; Peter Oelschlaeger; Michael W Crowder
Journal:  Bioorg Med Chem Lett       Date:  2013-09-08       Impact factor: 2.823

Review 4.  Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors.

Authors:  Anou M Somboro; John Osei Sekyere; Daniel G Amoako; Sabiha Y Essack; Linda A Bester
Journal:  Appl Environ Microbiol       Date:  2018-08-31       Impact factor: 4.792

5.  An Update on the Status of Potent Inhibitors of Metallo-β-Lactamases.

Authors:  Nazar Ul Islam
Journal:  Sci Pharm       Date:  2013-03-28

Review 6.  Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria.

Authors:  Yuan Liu; Ziwen Tong; Jingru Shi; Ruichao Li; Mathew Upton; Zhiqiang Wang
Journal:  Theranostics       Date:  2021-03-04       Impact factor: 11.556

7.  Semi-rational screening of the inhibitors and β-lactam antibiotics against the New Delhi metallo-β-lactamase 1 (NDM-1) producing E. coli.

Authors:  Juan Wang; Yang Li; Haizhong Yan; Juan Duan; Xihua Luo; Xueqin Feng; Lanfen Lu; Weijia Wang
Journal:  RSC Adv       Date:  2018-02-07       Impact factor: 4.036

8.  Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach.

Authors:  Glauber V Da Costa; Moysés F A Neto; Alicia K P Da Silva; Ester M F De Sá; Luanne C F Cancela; Jeanina S Vega; Cássio M Lobato; Juliana P Zuliani; José M Espejo-Román; Joaquín M Campos; Franco H A Leite; Cleydson B R Santos
Journal:  Int J Mol Sci       Date:  2022-07-26       Impact factor: 6.208

9.  Development of Hydroxamic Acid Compounds for Inhibition of Metallo-β-Lactamase from Bacillus anthracis.

Authors:  Andrew E Huckleby; Jhawn G Saul; Hyunshun Shin; Staci Desmarais; Apparao Bokka; Junha Jeon; Sung-Kun Kim
Journal:  Int J Mol Sci       Date:  2022-08-15       Impact factor: 6.208

10.  A general concept for the introduction of hydroxamic acids into polymers.

Authors:  Tobias Johann; Jennifer Keth; Matthias Bros; Holger Frey
Journal:  Chem Sci       Date:  2019-06-17       Impact factor: 9.825
  10 in total

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