Gary G Schwartz1, Halcyon G Skinner. 1. Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. gschwart@wfubmc.edu
Abstract
PURPOSE OF REVIEW: The aim of this article is to describe recent developments in human studies of the role of vitamin D in the etiology and treatment of cancer. RECENT FINDINGS: Epidemiologic studies over the past year lend additional support for important roles for vitamin D in the natural history of several cancers. Studies showing risk reduction by vitamin D in prostate, colon and breast cancers were joined by new analyses of endometrial, skin, and pancreatic cancers. Interest in vitamin D has extended to examinations of its influence on premalignant conditions such as adenomatous polyps and breast density. Studies of vitamin D and cancer survival have featured prominently in the recent literature. Sun exposure and indicators of high vitamin D status were found to be associated with improved survival for cutaneous melanoma, Hodgkin's lymphoma, and cancers of the lung, breast, prostate and colon. Therapeutic trials of vitamin D are especially prominent in the treatment of prostate cancer. SUMMARY: Studies over the past year indicate potentially important roles for vitamin D in cancer prevention, survival and treatment.
PURPOSE OF REVIEW: The aim of this article is to describe recent developments in human studies of the role of vitamin D in the etiology and treatment of cancer. RECENT FINDINGS: Epidemiologic studies over the past year lend additional support for important roles for vitamin D in the natural history of several cancers. Studies showing risk reduction by vitamin D in prostate, colon and breast cancers were joined by new analyses of endometrial, skin, and pancreatic cancers. Interest in vitamin D has extended to examinations of its influence on premalignant conditions such as adenomatous polyps and breast density. Studies of vitamin D and cancer survival have featured prominently in the recent literature. Sun exposure and indicators of high vitamin D status were found to be associated with improved survival for cutaneous melanoma, Hodgkin's lymphoma, and cancers of the lung, breast, prostate and colon. Therapeutic trials of vitamin D are especially prominent in the treatment of prostate cancer. SUMMARY: Studies over the past year indicate potentially important roles for vitamin D in cancer prevention, survival and treatment.
Authors: Jennifer L Kelly; Jonathan W Friedberg; Laura M Calvi; Edwin van Wijngaarden; Susan G Fisher Journal: Cancer Causes Control Date: 2010-04-07 Impact factor: 2.506
Authors: Jennifer L Kelly; Jonathan W Friedberg; Laura M Calvi; Edwin van Wijngaarden; Susan G Fisher Journal: Cancer Invest Date: 2009-11 Impact factor: 2.176
Authors: Jennifer L Kelly; Gilles Salles; Bryan Goldman; Richard I Fisher; Pauline Brice; Oliver Press; Olivier Casasnovas; David G Maloney; Pierre Soubeyran; Lisa Rimsza; Corinne Haioun; Luc Xerri; Michael LeBlanc; Hervé Tilly; Jonathan W Friedberg Journal: J Clin Oncol Date: 2015-03-30 Impact factor: 44.544
Authors: Robert J Freishtat; Sabah F Iqbal; Dinesh K Pillai; Catherine J Klein; Leticia M Ryan; Angela S Benton; Stephen J Teach Journal: J Pediatr Date: 2010-03-16 Impact factor: 4.406