Robert J Freishtat1, Sabah F Iqbal2, Dinesh K Pillai3, Catherine J Klein4, Leticia M Ryan5, Angela S Benton6, Stephen J Teach5. 1. Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC; Division of Emergency Medicine, Children's National Medical Center, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address: rfreishtat@cnmcresearch.org. 2. Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC; Division of Emergency Medicine, Children's National Medical Center, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC. 3. Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC; Division of Pulmonary Medicine, Children's National Medical Center, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC. 4. Center for Clinical and Community Research, Children's National Medical Center, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. 5. Center for Clinical and Community Research, Children's National Medical Center, Washington, DC; Division of Emergency Medicine, Children's National Medical Center, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. 6. Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC.
Abstract
OBJECTIVE: The goal of this study was to examine the prevalence of vitamin D insufficiency and deficiency among urban African-American (AA) youth with asthma compared with control subjects without asthma. STUDY DESIGN: A cross-sectional case-control study was conducted at an urban pediatric medical center. Total 25-hydroxyvitamin D insufficiency (<30 ng/mL) and deficiency (<20 ng/mL) were assessed in urban self-reported AA patients, aged 6 to 20 years, with (n = 92) and without (n = 21) physician-diagnosed asthma. RESULTS: Blood samples were available for 85 (92%) cases. The prevalence of vitamin D insufficiency and deficiency were significantly greater among cases than control subjects (73/85 [86%] vs 4/21 [19%], adjusted odds ratio = 42 [95% confidence interval: 4.4 to 399] for insufficiency and 46/85 [54%] vs 1/21 [5%], adjusted odds ratio = 20 [95% confidence interval: 1.4 to 272] for deficiency). CONCLUSIONS: Most of this sample of urban AA youth with persistent asthma were vitamin D deficient or insufficient. Given the emerging associations between low vitamin D levels and asthma, strong consideration should be given to routine vitamin D testing in urban AA youth, particularly those with asthma. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: The goal of this study was to examine the prevalence of vitamin D insufficiency and deficiency among urban African-American (AA) youth with asthma compared with control subjects without asthma. STUDY DESIGN: A cross-sectional case-control study was conducted at an urban pediatric medical center. Total 25-hydroxyvitamin Dinsufficiency (<30 ng/mL) and deficiency (<20 ng/mL) were assessed in urban self-reported AA patients, aged 6 to 20 years, with (n = 92) and without (n = 21) physician-diagnosed asthma. RESULTS: Blood samples were available for 85 (92%) cases. The prevalence of vitamin D insufficiency and deficiency were significantly greater among cases than control subjects (73/85 [86%] vs 4/21 [19%], adjusted odds ratio = 42 [95% confidence interval: 4.4 to 399] for insufficiency and 46/85 [54%] vs 1/21 [5%], adjusted odds ratio = 20 [95% confidence interval: 1.4 to 272] for deficiency). CONCLUSIONS: Most of this sample of urban AA youth with persistent asthma were vitamin D deficient or insufficient. Given the emerging associations between low vitamin D levels and asthma, strong consideration should be given to routine vitamin D testing in urban AA youth, particularly those with asthma. Copyright 2010 Mosby, Inc. All rights reserved.
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