Literature DB >> 17142813

Exploiting large scale computing to construct high resolution linkage disequilibrium maps of the human genome.

Winston Lau1, Tai-Yue Kuo, William Tapper, Simon Cox, Andrew Collins.   

Abstract

UNLABELLED: Linkage disequilibrium (LD) maps increase power and precision in association mapping, define optimal marker spacing and identify recombination hot-spots and regions influenced by natural selection. Phase II of HapMap provides approximately 2.8-fold more single nucleotide polymorphisms (SNPs) than phase I for constructing higher resolution maps. LDMAP-cluster, is a parallel program for rapid map construction in a Linux environment used here to construct genome-wide LD maps with >8.2 million SNPs from the phase II data. AVAILABILITY: The LD maps, LDMAP-cluster and documentation are available from: http://www.som.soton.ac.uk/research/geneticsdiv/epidemiology/LDMAP. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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Year:  2006        PMID： 17142813     DOI： 10.1093/bioinformatics/btl615

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  18 in total

1.  Dissecting the genetics of complex inheritance: linkage disequilibrium mapping provides insight into Crohn disease.

Authors:  Heather Elding; Winston Lau; Dallas M Swallow; Nikolas Maniatis
Journal:  Am J Hum Genet       Date:  2011-12-09       Impact factor: 11.025

2.  CHROMSCAN: genome-wide association using a linkage disequilibrium map.

Authors:  Andrew Collins; Winston Lau
Journal:  J Hum Genet       Date:  2007-11-28       Impact factor: 3.172

3.  A multimetric approach to analysis of genome-wide association by single markers and composite likelihood.

Authors:  Jane Gibson; William Tapper; David Cox; Weihua Zhang; Arne Pfeufer; Christian Gieger; H-Erich Wichmann; Stefan Kääb; Andrew R Collins; Thomas Meitinger; Newton Morton
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-11       Impact factor: 11.205

Review 4.  Allelic association: linkage disequilibrium structure and gene mapping.

Authors:  Andrew Collins
Journal:  Mol Biotechnol       Date:  2008-10-08       Impact factor: 2.695

5.  Refinement in localization and identification of gene regions associated with Crohn disease.

Authors:  Heather Elding; Winston Lau; Dallas M Swallow; Nikolas Maniatis
Journal:  Am J Hum Genet       Date:  2012-12-13       Impact factor: 11.025

6.  Exome-based linkage disequilibrium maps of individual genes: functional clustering and relationship to disease.

Authors:  Jane Gibson; William Tapper; Sarah Ennis; Andrew Collins
Journal:  Hum Genet       Date:  2012-11-04       Impact factor: 4.132

7.  Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations.

Authors:  Enrique Santiago; Armando Caballero
Journal:  Genetics       Date:  2016-09-26       Impact factor: 4.562

8.  Gene-dense autosomal chromosomes show evidence for increased selection.

Authors:  M Reza Jabalameli; Clare Horscroft; Alejandra Vergara-Lope; Reuben J Pengelly; Andrew Collins
Journal:  Heredity (Edinb)       Date:  2019-10-01       Impact factor: 3.821

9.  Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

Authors:  Damien C Croteau-Chonka; Amanda F Marvelle; Ethan M Lange; Nanette R Lee; Linda S Adair; Leslie A Lange; Karen L Mohlke
Journal:  Obesity (Silver Spring)       Date:  2010-10-21       Impact factor: 5.002

10.  TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.

Authors:  Andrew Chase; Thomas Ernst; Andreas Fiebig; Andrew Collins; Francis Grand; Philipp Erben; Andreas Reiter; Stefan Schreiber; Nicholas C P Cross
Journal:  Haematologica       Date:  2009-10-01       Impact factor: 9.941
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