Literature DB >> 17140807

Large common fragile site genes and cancer.

David I Smith1, Sarah McAvoy, Yu Zhu, Damon S Perez.   

Abstract

The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.

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Year:  2006        PMID： 17140807     DOI： 10.1016/j.semcancer.2006.10.003

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  51 in total

1.  Molecular profiling of common fragile sites in human fibroblasts.

Authors:  Benoî Le Tallec; Bernard Dutrillaux; Anne-Marie Lachages; Gael Armel Millot; Olivier Brison; Michelle Debatisse
Journal:  Nat Struct Mol Biol       Date:  2011-11-06       Impact factor: 15.369

2.  Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.

Authors:  Lena M Brueckner; Evgeny Sagulenko; Elisa M Hess; Diana Zheglo; Anne Blumrich; Manfred Schwab; Larissa Savelyeva
Journal:  Hum Genet       Date:  2012-04-05       Impact factor: 4.132

3.  Oncogenes create a unique landscape of fragile sites.

Authors:  Karin Miron; Tamar Golan-Lev; Raz Dvir; Eyal Ben-David; Batsheva Kerem
Journal:  Nat Commun       Date:  2015-05-11       Impact factor: 14.919

Review 4.  Impediments to replication fork movement: stabilisation, reactivation and genome instability.

Authors:  Sarah Lambert; Antony M Carr
Journal:  Chromosoma       Date:  2013-02-28       Impact factor: 4.316

5.  Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines.

Authors:  Jun Mitsui; Yuji Takahashi; Jun Goto; Hiroyuki Tomiyama; Shunpei Ishikawa; Hiroyo Yoshino; Narihiro Minami; David I Smith; Suzanne Lesage; Hiroyuki Aburatani; Ichizo Nishino; Alexis Brice; Nobutaka Hattori; Shoji Tsuji
Journal:  Am J Hum Genet       Date:  2010-07-09       Impact factor: 11.025

6.  Genome wide DNA-profiling of HIV-related B-cell lymphomas.

Authors:  Daniela Capello; Marta Scandurra; Giulia Poretti; Paola M V Rancoita; Michael Mian; Annunziata Gloghini; Clara Deambrogi; Maurizio Martini; Davide Rossi; Timothy C Greiner; Wing C Chan; Maurilio Ponzoni; Santiago M Moreno; Miguel A Piris; Vincenzo Canzonieri; Michele Spina; Umberto Tirelli; Giorgio Inghirami; Andrea Rinaldi; Emanuele Zucca; Riccardo D Favera; Franco Cavalli; Luigi Maria Larocca; Ivo Kwee; Antonino Carbone; Gianluca Gaidano; Francesco Bertoni
Journal:  Br J Haematol       Date:  2009-10-12       Impact factor: 6.998

7.  Fragile genomic sites are associated with origins of replication.

Authors:  Sara C Di Rienzi; David Collingwood; M K Raghuraman; Bonita J Brewer
Journal:  Genome Biol Evol       Date:  2009-09-09       Impact factor: 3.416

8.  Common fragile sites are characterized by histone hypoacetylation.

Authors:  Yanwen Jiang; Isabelle Lucas; David J Young; Elizabeth M Davis; Theodore Karrison; Joshua S Rest; Michelle M Le Beau
Journal:  Hum Mol Genet       Date:  2009-08-28       Impact factor: 6.150

9.  Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats.

Authors:  Meng-Yen Li; Feng-Jie Lai; Li-Jin Hsu; Chen-Peng Lo; Ching-Li Cheng; Sing-Ru Lin; Ming-Hui Lee; Jean-Yun Chang; Dudekula Subhan; Ming-Shu Tsai; Chun-I Sze; Subbiah Pugazhenthi; Nan-Shan Chang; Shur-Tzu Chen
Journal:  PLoS One       Date:  2009-11-12       Impact factor: 3.240

10.  DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.

Authors:  Sandeep N Shah; Patricia L Opresko; Xiao Meng; Marietta Y W T Lee; Kristin A Eckert
Journal:  Nucleic Acids Res       Date:  2009-12-06       Impact factor: 16.971
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