Literature DB >> 17139521

[Schizophrenia, human genetics and genetic counselling. Human genetic counselling as part of the psychiatric/psychotherapeutic treatment concept].

H Knoblauch1.   

Abstract

The human genome project has substantially increased our knowledge about the genetic basis of psychiatric diseases. In daily clinical practice the physician is asked about the diagnosis of genetically dependent diseases with an increased psychiatric risk, particularly schizophrenia group disorders, about the recurrence risk of psychiatric diseases in the relatives and children of the patients, on the use of psychopharmaceuticals during pregnancy and their potential consequences for the offspring, as well as psychopharmacogenetics. These questions will be dealt with in this contribution. At present, they receive too little attention, although genetic counselling might play an important role within the framework of psychiatric treatment, especially for schizophrenia. Such counselling should be seen as a component of the psychiatric/psychotherapeutic treatment concept and performed according to human genetic guidelines.

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Year:  2007        PMID: 17139521     DOI: 10.1007/s00115-006-2209-5

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  20 in total

1.  Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.

Authors:  Sibylle G Schwab; Michael Knapp; Stephanie Mondabon; Joachim Hallmayer; Margitta Borrmann-Hassenbach; Margot Albus; Bernard Lerer; Marcella Rietschel; Matyas Trixler; Wolfgang Maier; Dieter B Wildenauer
Journal:  Am J Hum Genet       Date:  2002-12-09       Impact factor: 11.025

Review 2.  An update on the molecular genetics of congenital adrenal hyperplasia: diagnostic and therapeutic aspects.

Authors:  A Wedell
Journal:  J Pediatr Endocrinol Metab       Date:  1998 Sep-Oct       Impact factor: 1.634

Review 3.  Schizophrenia and velo-cardio-facial syndrome.

Authors:  Kieran C Murphy
Journal:  Lancet       Date:  2002-02-02       Impact factor: 79.321

4.  Clinical features and reproductive patterns in fragile X female heterozygotes.

Authors:  D Z Loesch; D A Hay
Journal:  J Med Genet       Date:  1988-06       Impact factor: 6.318

Review 5.  Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Authors:  Robert W Mahley; Karl H Weisgraber; Yadong Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

Review 6.  Genetic counselling for schizophrenia in the era of molecular genetics.

Authors:  K A Hodgkinson; J Murphy; S O'Neill; L Brzustowicz; A S Bassett
Journal:  Can J Psychiatry       Date:  2001-03       Impact factor: 4.356

7.  Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families.

Authors:  Xiangning Chen; Cynthia Dunham; Seth Kendler; Xu Wang; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2004-08-15       Impact factor: 3.568

Review 8.  Neuregulin 1 and schizophrenia.

Authors:  Hreinn Stefansson; Valgerdur Steinthorsdottir; Thorgeir E Thorgeirsson; Jeffrey R Gulcher; Kari Stefansson
Journal:  Ann Med       Date:  2004       Impact factor: 4.709

9.  The schizophrenia phenotype in 22q11 deletion syndrome.

Authors:  Anne S Bassett; Eva W C Chow; Philip AbdelMalik; Mirona Gheorghiu; Janice Husted; Rosanna Weksberg
Journal:  Am J Psychiatry       Date:  2003-09       Impact factor: 18.112

Review 10.  The genetics of autism.

Authors:  Rebecca Muhle; Stephanie V Trentacoste; Isabelle Rapin
Journal:  Pediatrics       Date:  2004-05       Impact factor: 7.124

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