Literature DB >> 17139253

NoRC-dependent nucleosome positioning silences rRNA genes.

Junwei Li1, Gernot Längst, Ingrid Grummt.   

Abstract

Previous studies have established that the Snf2h-containing chromatin remodeling complex NoRC mediates epigenetic silencing of a subset of rRNA genes (rDNA) by recruiting enzymatic activities that modify histones and methylate DNA. Here we have analyzed nucleosome positions at the murine rDNA promoter and show that active and silent rDNA copies are characterized not only by specific epigenetic marks but also by differently positioned nucleosomes. At active genes the promoter-bound nucleosome covers nucleotides from -157 to -2, whereas at silent genes the nucleosome is positioned 25 nucleotides further downstream. We provide evidence that NoRC is the molecular machine that shifts the promoter-bound nucleosome downstream of the transcription start site into a translational position that is unfavorable for transcription complex formation.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17139253      PMCID： PMC1698900          DOI： 10.1038/sj.emboj.7601454

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  30 in total

1.  DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules.

Authors:  V Y Stefanovsky; G Pelletier; D P Bazett-Jones; C Crane-Robinson; T Moss
Journal:  Nucleic Acids Res       Date:  2001-08-01       Impact factor: 16.971

2.  Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation.

Authors:  Evi Soutoglou; Iannis Talianidis
Journal:  Science       Date:  2002-03-08       Impact factor: 47.728

3.  Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation.

Authors:  A B Fleming; S Pennings
Journal:  EMBO J       Date:  2001-09-17       Impact factor: 11.598

4.  Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription.

Authors:  R Santoro; I Grummt
Journal:  Mol Cell       Date:  2001-09       Impact factor: 17.970

Review 5.  Epigenetic silencing of RNA polymerase I transcription.

Authors:  Ingrid Grummt; Craig S Pikaard
Journal:  Nat Rev Mol Cell Biol       Date:  2003-08       Impact factor: 94.444

6.  Ssn6-Tup1 regulates RNR3 by positioning nucleosomes and affecting the chromatin structure at the upstream repression sequence.

Authors:  B Li; J C Reese
Journal:  J Biol Chem       Date:  2001-07-11       Impact factor: 5.157

Review 7.  Nucleolar dominance: a model for rRNA gene silencing.

Authors:  Brian McStay
Journal:  Genes Dev       Date:  2006-05-15       Impact factor: 11.361

8.  Roles of transcription factor Mot3 and chromatin in repression of the hypoxic gene ANB1 in yeast.

Authors:  A J Kastaniotis; T A Mennella; C Konrad; A M Torres; R S Zitomer
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

9.  NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.

Authors:  R Strohner; A Nemeth; P Jansa; U Hofmann-Rohrer; R Santoro; G Längst; I Grummt
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

10.  The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.

Authors:  Raffaella Santoro; Junwei Li; Ingrid Grummt
Journal:  Nat Genet       Date:  2002-10-07       Impact factor: 38.330
View more
  53 in total

1.  Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.

Authors:  Julia Hochstatter; Michael Hölzel; Michaela Rohrmoser; Lothar Schermelleh; Heinrich Leonhardt; Rebecca Keough; Thomas J Gonda; Axel Imhof; Dirk Eick; Gernot Längst; Attila Németh
Journal:  J Biol Chem       Date:  2012-05-29       Impact factor: 5.157

Review 2.  Nucleolar DNA: the host and the guests.

Authors:  E Smirnov; D Cmarko; T Mazel; M Hornáček; I Raška
Journal:  Histochem Cell Biol       Date:  2016-02-04       Impact factor: 4.304

3.  The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions.

Authors:  Wenbing Xie; Te Ling; Yonggang Zhou; Weijun Feng; Qiaoyun Zhu; Henk G Stunnenberg; Ingrid Grummt; Wei Tao
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-08       Impact factor: 11.205

Review 4.  Nucleosome remodeling and epigenetics.

Authors:  Peter B Becker; Jerry L Workman
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-09-01       Impact factor: 10.005

Review 5.  Noisy silence: non-coding RNA and heterochromatin formation at repetitive elements.

Authors:  Holger Bierhoff; Anna Postepska-Igielska; Ingrid Grummt
Journal:  Epigenetics       Date:  2013-10-11       Impact factor: 4.528

6.  Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae.

Authors:  John E Mueller; Mary Bryk
Journal:  J Mol Biol       Date:  2007-05-18       Impact factor: 5.469

7.  A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.

Authors:  Irina Anosova; Svitlana Melnik; Konstantinos Tripsianes; Fatiha Kateb; Ingrid Grummt; Michael Sattler
Journal:  Nucleic Acids Res       Date:  2015-04-27       Impact factor: 16.971

8.  Chromatin Remodeling Factors Isw2 and Ino80 Regulate Chromatin, Replication, and Copy Number of the Saccharomyces cerevisiae Ribosomal DNA Locus.

Authors:  Sam Cutler; Laura J Lee; Toshio Tsukiyama
Journal:  Genetics       Date:  2018-10-24       Impact factor: 4.562

9.  FACT facilitates chromatin transcription by RNA polymerases I and III.

Authors:  Joanna L Birch; Bertrand C-M Tan; Kostya I Panov; Tatiana B Panova; Jens S Andersen; Tom A Owen-Hughes; Jackie Russell; Sheng-Chung Lee; Joost C B M Zomerdijk
Journal:  EMBO J       Date:  2009-02-12       Impact factor: 11.598

10.  UBF levels determine the number of active ribosomal RNA genes in mammals.

Authors:  Elaine Sanij; Gretchen Poortinga; Kerith Sharkey; Sandy Hung; Timothy P Holloway; Jaclyn Quin; Elysia Robb; Lee H Wong; Walter G Thomas; Victor Stefanovsky; Tom Moss; Lawrence Rothblum; Katherine M Hannan; Grant A McArthur; Richard B Pearson; Ross D Hannan
Journal:  J Cell Biol       Date:  2008-12-22       Impact factor: 10.539
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.