Literature DB >> 26847178

Nucleolar DNA: the host and the guests.

E Smirnov1, D Cmarko2, T Mazel2, M Hornáček2, I Raška2.   

Abstract

Nucleoli are formed on the basis of ribosomal genes coding for RNAs of ribosomal particles, but also include a great variety of other DNA regions. In this article, we discuss the characteristics of ribosomal DNA: the structure of the rDNA locus, complex organization and functions of the intergenic spacer, multiplicity of gene copies in one cell, selective silencing of genes and whole gene clusters, relation to components of nucleolar ultrastructure, specific problems associated with replication. We also review current data on the role of non-ribosomal DNA in the organization and function of nucleoli. Finally, we discuss probable causes preventing efficient visualization of DNA in nucleoli.

Keywords:  DNA staining; NADs; Nucleolus; Replication; Transcription activity; rDNA

Mesh：

Substances：

Year:  2016        PMID： 26847178     DOI： 10.1007/s00418-016-1407-x

Source DB:  PubMed          Journal:  Histochem Cell Biol        ISSN： 0948-6143            Impact factor:   4.304


  233 in total

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  16 in total

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