OBJECTIVE: In Japanese individuals, the -169C/T single-nucleotide polymorphism (SNP) in FCRL3 has been reported to be associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and autoimmune thyroid diseases. The objective of this study was to test the association of this SNP with RA and SLE, in a case-control study of Korean individuals. METHODS: The -169C/T SNP in FCRL3 was genotyped in 1,060 patients with RA, 457 patients with SLE, and 697 unaffected control subjects, using the MassARRAY SNP genotyping system. Associations were tested by multivariate logistic regression, with adjustments for age and sex. RESULTS: No association was detected between the -169C/T SNP and RA (odds ratio [OR] 1.11, 95% confidence interval [95% CI] 0.83-1.48, P = 0.50) or SLE (OR 1.00, 95% CI 0.73-1.37, P = 0.99). This SNP was not associated with rheumatoid factor status, shared epitope status, radiographic severity in patients with RA, or disease manifestations in patients with SLE. CONCLUSION: The association of the -169C/T SNP in FCRL3 with RA and SLE that was observed in Japanese patients was not replicated in a Korean population.
OBJECTIVE: In Japanese individuals, the -169C/T single-nucleotide polymorphism (SNP) in FCRL3 has been reported to be associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and autoimmune thyroid diseases. The objective of this study was to test the association of this SNP with RA and SLE, in a case-control study of Korean individuals. METHODS: The -169C/T SNP in FCRL3 was genotyped in 1,060 patients with RA, 457 patients with SLE, and 697 unaffected control subjects, using the MassARRAY SNP genotyping system. Associations were tested by multivariate logistic regression, with adjustments for age and sex. RESULTS: No association was detected between the -169C/T SNP and RA (odds ratio [OR] 1.11, 95% confidence interval [95% CI] 0.83-1.48, P = 0.50) or SLE (OR 1.00, 95% CI 0.73-1.37, P = 0.99). This SNP was not associated with rheumatoid factor status, shared epitope status, radiographic severity in patients with RA, or disease manifestations in patients with SLE. CONCLUSION: The association of the -169C/T SNP in FCRL3 with RA and SLE that was observed in Japanese patients was not replicated in a Korean population.
Authors: J F Mendoza Rincón; A K Rodríguez Elias; J M Fragoso; G Vargas Alarcón; K Maldonado Murillo; M L Rivas Jiménez; R E Barbosa Cobos; S Jimenez Morales; G Lugo Zamudio; C Tovilla Zárate; J Ramírez Bello Journal: Rheumatol Int Date: 2015-09-08 Impact factor: 2.631
Authors: Andrew W Gibson; Fu Jun Li; Jianming Wu; Jeffrey C Edberg; Kaihong Su; John Cafardi; Howard Wiener; Hemant Tiwari; Robert P Kimberly; Randall S Davis Journal: Arthritis Rheum Date: 2009-11
Authors: Hanna W van Steenbergen; Luis Rodríguez-Rodríguez; Ewa Berglin; Alexandra Zhernakova; Rachel Knevel; Jose Ivorra-Cortés; Tom W J Huizinga; Benjamin Fernández-Gutiérrez; Peter K Gregersen; Solbritt Rantapää-Dahlqvist; Annette H M van der Helm-van Mil Journal: Arthritis Res Ther Date: 2015-01-08 Impact factor: 5.156
Authors: Monica Chang; Charles M Rowland; Veronica E Garcia; Steven J Schrodi; Joseph J Catanese; Annette H M van der Helm-van Mil; Kristin G Ardlie; Christopher I Amos; Lindsey A Criswell; Daniel L Kastner; Peter K Gregersen; Fina A S Kurreeman; Rene E M Toes; Tom W J Huizinga; Michael F Seldin; Ann B Begovich Journal: PLoS Genet Date: 2008-06-27 Impact factor: 5.917